LRP 4 antibodies in serum and CSF from amyotrophic lateral sclerosis patients

JS Tzartos, P Zisimopoulou, M Rentzos… - Annals of clinical …, 2014 - Wiley Online Library
Objective Amyotrophic lateral sclerosis (ALS) and myasthenia gravis (MG) are caused,
respectively, by motor neuron degeneration and neuromuscular junction (NMJ) dysfunction …

Anti-LRP4 autoantibodies in AChR-and MuSK-antibody-negative myasthenia gravis

A Pevzner, B Schoser, K Peters, NC Cosma… - Journal of …, 2012 - Springer
Myasthenia gravis (MG) is an autoimmune disorder characterized by a defect in synaptic
transmission at the neuromuscular junction causing fluctuating muscle weakness with a …

[HTML][HTML] Flow cytofluorimetric analysis of anti-LRP4 (LDL receptor-related protein 4) autoantibodies in Italian patients with myasthenia gravis

M Marino, F Scuderi, D Samengo, G Saltelli, MT Maiuri… - PloS one, 2015 - journals.plos.org
Background Myasthenia gravis (MG) is an autoimmune disease in which 90% of patients
have autoantibodies against the muscle nicotinic acetylcholine receptor (AChR), while …

Anti‐LRP4 autoantibodies in Chinese patients with myasthenia gravis

Y Li, Y Zhang, G Cai, D He, Q Dai, Z Xu… - Muscle & nerve, 2017 - Wiley Online Library
Introduction We assessed antibodies against low‐density lipoprotein receptor‐related
protein 4 (LRP4‐Ab) in a Chinese population with myasthenia gravis (MG). Methods Serum …

Autoantibodies to lipoprotein-related protein 4 in patients with double-seronegative myasthenia gravis

B Zhang, JS Tzartos, M Belimezi, S Ragheb… - Archives of …, 2012 - jamanetwork.com
Objectives To determine whether patients with myasthenia gravis (MG) have serum
antibodies to lipoprotein-related protein 4 (LRP4), a newly identified receptor for agrin that is …

A comprehensive analysis of the epidemiology and clinical characteristics of anti-LRP4 in myasthenia gravis

P Zisimopoulou, P Evangelakou, J Tzartos… - Journal of …, 2014 - Elsevier
Double-seronegative myasthenia gravis (dSN-MG, without detectable AChR and MuSK
antibodies) presents a serious gap in MG diagnosis and understanding. Recently …

LRP4-IgG service line testing in seronegative myasthenia gravis and controls

CJ Klein, G Beecher, C Lamb, E Naddaf… - Journal of …, 2022 - Elsevier
Background LRP4 is a post-synaptic membrane protein that promotes acetylcholine (AChR)
clustering on the crest of post-synaptic neuromuscular folds. Autoantibodies against LRP4 …

Clinical analysis of Chinese anti‐low‐density‐lipoprotein‐receptor‐associated protein 4 antibodies in patients with myasthenia gravis

M Li, J Han, Y Zhang, J Lv, J Zhang… - European Journal of …, 2019 - Wiley Online Library
Background and purpose Low‐density‐lipoprotein‐receptor‐associated protein 4 (LRP4)
autoantibodies have recently been detected in myasthenia gravis (MG), but little is known …

[HTML][HTML] Immunization of mice with LRP4 induces myasthenia similar to MuSK-associated myasthenia gravis

S Mori, N Motohashi, R Takashima, M Kishi… - Experimental …, 2017 - Elsevier
Since the first report of experimental animal models of myasthenia gravis (MG) with
autoantibodies against low-density lipoprotein receptor-related protein 4 (LRP4), there have …

Autoantibodies to low‐density lipoprotein receptor–related protein 4 in myasthenia gravis

O Higuchi, J Hamuro, M Motomura… - Annals of …, 2011 - Wiley Online Library
Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction, where
acetylcholine receptor (AChR), muscle‐specific kinase (MuSK), and low‐density lipoprotein …