High-mobility group box-1 (HMGB1), a ubiquitous nuclear protein, acts as a late mediator of
lethality when released extracellularly during sepsis. The major source of circulating HMGB1 …

Ischemia and reperfusion (I/R) injury is an often unavoidable consequence of major liver
surgery and is characterized by a sterile inflammatory response that jeopardizes the viability …

Burns are associated with activation of the innate immunity that can contribute to
complications. Damage-associated molecular patterns (DAMPs) released after tissue injury …

Endogenous damage-associated molecular pattern (DAMP) molecules are released from
cells during traumatic injury, allowing them to interact with pattern recognition receptors such …

Acetaminophen overdose causes acute liver inflammation with neutrophil infiltration;
however, the mechanism of damage‐associated inflammation has not been elucidated. In …

Innate immune receptors for pathogen-and damage-associated molecular patterns (PAMPs
and DAMPs) orchestrate inflammatory responses to infection and injury. Secreted by …

High mobility group box protein 1 (HMGB1) acts as an endogenous danger molecule that is
released from necrotic cells and activated macrophages. We have previously shown that …

In response to bacterial endotoxin (eg, LPS) or endogenous proinflammatory cytokines (eg,
TNF and IL-1β), innate immune cells release HMGB1, a late cytokine mediator of lethal …

Dendritic cells (DCs) are potent antigen-presenting cells critical in regulating the adaptive
immune response. The role of DCs is dichotomous; they may both present antigens and the …

The damage-associated molecular pattern molecules (DAMPs) released by necrotic cells
can trigger inflammatory response, which will facilitate the clearance of these dead cells …