Acetaminophen overdose causes acute liver inflammation with neutrophil infiltration;
however, the mechanism of damage‐associated inflammation has not been elucidated. In …

Dendritic cells (DCs) are potent antigen-presenting cells critical in regulating the adaptive
immune response. The role of DCs is dichotomous; they may both present antigens and the …

High mobility group box protein 1 (HMGB1) acts as an endogenous danger molecule that is
released from necrotic cells and activated macrophages. We have previously shown that …

The damage-associated molecular pattern molecules (DAMPs) released by necrotic cells
can trigger inflammatory response, which will facilitate the clearance of these dead cells …

High-mobility group box 1 (HMGB1) is a 30-kDa DNA-binding protein that displays
proinflammatory cytokine-like properties. HMGB1-dependent inflammatory processes have …

Hepatocyte-specific HMGB1 deletion has been found to worsen the injury and inflammation
in liver ischemia-reperfusion injury (IRI), highlighting a role for intracellular HMGB1 in …

Acute liver failure (ALF) is a highly complex syndrome characterized by devastating
activation of early activation of Kupffer cells (KCs) has been implicated in the pathogenesis …

High-mobility group box 1 (HMGB1) is an abundant architectural chromosomal protein that
has multiple biologic functions: gene transcription, DNA replication, DNA-damage repair …

Liver interstitial dendritic cells (DCs) have been implicated in the control of ischemia–
reperfusion injury (IRI) and host immune responses following liver transplantation …

Damage-associated molecular patterns (DAMPs) comprise intracellular molecules
characterized by the ability to reach the extracellular environment, where they prompt …