Introduction Aberrant DNA methylation has been found frequently in human breast cancers,
associated with the loss of expression of a number of regulatory genes for growth and …

Aberrant DNA methylation is critical for development and progression of breast cancer. We
investigated the association of CpG island methylation in candidate genes and …

Aberrant hypermethylation of gene promoter regions is one of the mechanisms for
inactivation of tumour suppressor genes in breast cancer. We investigated whether …

Background: Hundreds of hypermethylated genes have been described in breast cancer, yet
the nature and contribution of these genes in their methylated state to overall risk and …

Introduction Estrogen receptor (ER)-positive breast cancers are considered prognostically
more favorable than ER-negative tumors, whereas human epidermal growth factor receptor …

Methylation of tumor suppressor genes has been implicated in breast cancer development.
However, methylation profiles of different breast lesions, subtypes of carcinoma in particular …

Background Aberrant DNA methylation of regulatory genes has frequently been found in
human breast cancers and correlated to clinical outcome. In the present study we investigate …

Purpose: Gene promoter region hypermethylation is a significant event in primary breast
cancer. However, its impact on tumor progression and potential predictive implications …

Background: Methylation-mediated suppression of detoxification, DNA repair and tumor
suppressor genes has been implicated in cancer development. This study was designed to …

Background In the present study, we determined the gene hypermethylation profiles of
normal tissues adjacent to invasive breast carcinomas and investigated whether these are …