Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects

N Møller, JOL Jørgensen - Endocrine reviews, 2009 - academic.oup.com
In evolutionary terms, GH and intracellular STAT 5 signaling is a very old regulatory system.
Whereas insulin dominates periprandially, GH may be viewed as the primary anabolic …

Growth hormone therapy and Quality of Life: possibilities, pitfalls and mechanisms.

KL Hull, S Harvey - The Journal of endocrinology, 2003 - europepmc.org
The actions of growth hormone (GH) are not restricted to growth: GH modulates metabolic
pathways as well as neural, reproductive, immune, cardiovascular, and pulmonary …

Drug insight: the functions of ghrelin and its potential as a multitherapeutic hormone

M Kojima, K Kangawa - Nature Clinical Practice Endocrinology & …, 2006 - nature.com
The endogenous ligand for the growth-hormone (GH) secretagogue receptor was purified
from stomach and named ghrelin. It has potent GH-releasing activity and stimulates appetite …

Effects of dose and gender on the growth and growth factor response to GH in GH-deficient children: implications for efficacy and safety

P Cohen, GM Bright, AD Rogol… - The Journal of …, 2002 - academic.oup.com
We evaluated the dose-response effects of GH on the growth and growth factor levels of GH-
deficient patients. One hundred eleven short (− 3.0±0.9 height sd score), prepubertal GH …

GH and ageing: Pitfalls and new insights

A Bartke, J Darcy - Best Practice & Research Clinical Endocrinology & …, 2017 - Elsevier
The interrelationships of growth hormone (GH) actions and aging are complex and
incompletely understood. The very pronounced age-related decline in GH secretion together …

Regulation of human growth hormone secretion and its disorders

Y Kato, Y Murakami, M Sohmiya, M Nishiki - Internal medicine, 2002 - jstage.jst.go.jp
Growthhormone (GH) secretion fromanterior pituitary is regulated by the hypothalamus and
the mediators of GH actions. Majorregulatory factors include GHreleasing hormone (GHRH) …

Evidence for growth hormone (GH) autoregulation in pituitary somatotrophs in GH antagonist-transgenic mice and GH receptor-deficient mice

SL Asa, KT Coschigano, L Bellush, JJ Kopchick… - The American journal of …, 2000 - Elsevier
Growth hormone (GH) modulates the hypothalamic release of somatostatin and GH-
releasing hormone; however, there has been no evidence of GH autoregulation on the …

High dose recombinant human growth hormone (GH) treatment of GH-deficient patients in puberty increases near-final height: a randomized, multicenter trial

N Mauras, KM Attie, EO Reiter… - The Journal of …, 2000 - academic.oup.com
GH production rates markedly increase during human puberty, mostly as an amplitude-
modulated phenomenon. However, GH-deficient children have been dosed on a standard …

Growth hormone receptor modulators

V Birzniece, A Sata, KKY Ho - Reviews in endocrine and metabolic …, 2009 - Springer
Growth hormone (GH) regulates somatic growth, substrate metabolism and body
composition. Its actions are elaborated through the GH receptor (GHR). GHR signalling …

Status of long-acting-growth hormone preparations—2015

C Høybye, P Cohen, AR Hoffman, R Ross… - Growth Hormone & IGF …, 2015 - Elsevier
Growth hormone (GH) treatment has been an established therapy for GH deficiency (GHD)
in children and adults for more than three decades. Numerous studies have shown that GH …