The development of programmable nucleases to introduce defined alterations in genomic
sequences has been a powerful tool for precision medicine. While several nucleases such …

The ongoing advent of genome editing with programmable nucleases, including zinc‐finger
nuclease (ZFN), TAL effector nuclease (TALEN), and Clustered Regularly Interspaced Short …

Advances in genome engineering in the last decade, particularly in the development of
programmable nucleases, have made it possible to edit the genomes of most cell types …

Highlights•CRISPR/Cas9 overcomes limitations of earlier targeted nuclease-mediated
methods.•CRISPR/Cas9 allows for insertions/deletions of multiple alleles in a single …

Highlights•Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 is a
powerful tool for genome editing in hematopoietic cells, including primary hematopoietic …

Genome editing technologies have advanced significantly over the past few years, providing
a fast and effective tool to precisely manipulate the genome at specific locations. The three …

Genome editing therapies represent a significant advancement in next‐generation,
precision medicine for the management of haematological diseases, and CRISPR/Cas9 has …

The use of precise, rationally designed gene-editing nucleases allows for targeted genome
and transcriptome modification, and at present, four major classes of nucleases are being …

Summary The Clustered Regularly Interspaced Short Palindromic Repeats
(CRISPR)/CRISPR‐associated (Cas) 9 platform offers an efficient way of making precise …

The recent advent of the Clustered Regularly Interspaced Short Palindromic Repeats
(CRISPR)‐CRISPR associated protein 9 (Cas9) system for precise genome editing has …