Hematopoietic stem and progenitor cells (HSPCs) have great therapeutic potential because
of their ability to both self-renew and differentiate. It has been proposed that, given their …

CRISPR/Cas genome editing is a simple, cost effective, and highly specific technique for
introducing genetic variations. In mammalian cells, CRISPR/Cas can facilitate non …

The recent development of CRISPR–Cas systems as easily accessible and programmable
tools for genome editing and regulation is spurring a revolution in biology. Paired with the …

Genome editing of hematopoietic stem and progenitor cells is being developed for the
treatment of several inherited disorders of the hematopoietic system. The adaptation of …

This narrative review examines the promising potential of integrating artificial intelligence
(AI) with CRISPR-Cas9 genome editing to advance CAR T-cell therapy. AI algorithms offer …

CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated protein
9) shows the opportunity to treat a diverse array of untreated various genetic and …

Molecular diagnostics is of critical importance to public health worldwide. It facilitates not
only detection and characterization of diseases, but also monitors drug responses, assists in …

Simple Summary We used PCR-generated small CRISPR constructs to edit two genes
(IDH2 and MYBL2) in hard-to-transfect hemopoietic cells, which are central to the …

Recent progress in developing programmable nucleases, such as zinc-finger nucleases,
transcription activator–like effector nucleases (TALENs) and clustered regularly interspaced …

A decade of progress in sequencing and in CRISPR/Cas technologies has created a
situation without precedent in the history of medicine. Starting with an individual patient, next …