Rationale: The contribution of aeration heterogeneity to lung injury during early mechanical
ventilation of uninjured lungs is unknown. Objectives: To test the hypotheses that a strategy …

Objective: The common denominator in most forms of ventilator-induced lung injury is an
intense inflammatory response mediated by neutrophils. PET with [18 F] fluoro-2-deoxy-D …

Background Protective mechanical ventilation (MV) aims at limiting global lung deformation
and has been associated with better clinical outcomes in acute respiratory distress …

Objectives: Sepsis-related lung injury is the most common and morbid form of acute lung
injury. The objective of this study was to develop an ovine model of septic acute lung injury …

Objective: It is known that ventilator-induced lung injury causes increased pulmonary
inflammation. It has been suggested that one of the underlying mechanisms may be strain …

Objectives: Determine the intra-tidal regional gas and blood volume distributions at different
levels of atelectasis in experimental lung injury. Test the hypotheses that pulmonary aeration …

Objective: In acute lung injury, recruitment maneuvers have been used to open collapsed
lungs and set positive end-expiratory pressure, but their effectiveness may depend on the …

Background There is limited information on the regional inflammatory effects of mechanical
ventilation and endotoxemia on the production of acute lung injury. Measurement of F …

Rationale: During acute lung injury (ALI), mechanical ventilation can aggravate inflammation
by promoting alveolar distension and cyclic recruitment–derecruitment. As an estimate of the …

Objective: Tidal volume (VT) and volume of gas caused by positive end-expiratory pressure
(V PEEP) generate dynamic and static lung strains, respectively. Our aim was to clarify …