Current pharmacogenomic approaches to clinical drug development
MP Murphy - Pharmacogenomics, 2000 - Taylor & Francis
Pharmacogenomics has recently become an integral part of the drug development process.
The pharmacogenomics revolution comes at a time when pharmaceutical companies are …
The pharmacogenomics revolution comes at a time when pharmaceutical companies are …
Clinical pharmacogenomics: applications in pharmaceutical R&D
RM Norton - Drug discovery today, 2001 - Elsevier
Within the pharmaceutical industry, the application of clinical pharmacogenomics promises
to enhance the discovery of drug response markers, reduce the size and expense of clinical …
to enhance the discovery of drug response markers, reduce the size and expense of clinical …
A pharmacogenomics primer
MH Court - The Journal of Clinical Pharmacology, 2007 - Wiley Online Library
The human genome project and related research initiatives have enabled the identification
of a significant number of genetic variants that are predictive of drug response and outcome …
of a significant number of genetic variants that are predictive of drug response and outcome …
[HTML][HTML] Pharmacogenomics in practice
L Wang, R Weinshilboum - Clinical pharmacology and …, 2019 - ncbi.nlm.nih.gov
Pharmacogenomics is an important aspect of clinical genomics that is touching an
increasingly large number of patients. That is because pharmacogenomic testing is being …
increasingly large number of patients. That is because pharmacogenomic testing is being …
[HTML][HTML] Pharmacogenomic biomarkers for improved drug therapy—recent progress and future developments
Much of the inter-individual variability in drug efficacy and risk of adverse reactions is due to
polymorphisms in genes encoding proteins involved in drug pharmacokinetics and …
polymorphisms in genes encoding proteins involved in drug pharmacokinetics and …
Scientific challenges and implementation barriers to translation of pharmacogenomics in clinical practice
YWF Lam - International Scholarly Research Notices, 2013 - Wiley Online Library
The mapping of the human genome and subsequent advancements in genetic technology
had provided clinicians and scientists an understanding of the genetic basis of altered drug …
had provided clinicians and scientists an understanding of the genetic basis of altered drug …
Pharmacogenetics at 50: genomic personalization comes of age
TJ Urban, DB Goldstein - Science translational medicine, 2014 - science.org
The study of the genetics of drug responses has a long history but has provided only a few
examples of gene variants that are relevant clinically. Here, we discuss the current state of …
examples of gene variants that are relevant clinically. Here, we discuss the current state of …
A genomic “roadmap” to “better” drugs
G Liao, X Zhang, DJ Clark, G Peltz - Drug metabolism reviews, 2008 - Taylor & Francis
Utilization of pharmacogenomic information has the potential to significantly improve
treatment outcome and markedly reduce the rate of attrition of drugs in clinical development …
treatment outcome and markedly reduce the rate of attrition of drugs in clinical development …
Pharmacogenetics and pharmacogenomics
Pharmacogenomics is a growing field of research that links genetic variation with drug
effects to determine impact on pharmacology and clinical application. Relationships …
effects to determine impact on pharmacology and clinical application. Relationships …
Progress towards the integration of pharmacogenomics in practice
SD Mooney - Human genetics, 2015 - Springer
Understanding the role genes and genetic variants play in clinical treatment response
continues to be an active area of research with the goal of common clinical use. This goal …
continues to be an active area of research with the goal of common clinical use. This goal …
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