Current pharmacogenomic approaches to clinical drug development

MP Murphy - Pharmacogenomics, 2000 - Taylor & Francis
Pharmacogenomics has recently become an integral part of the drug development process.
The pharmacogenomics revolution comes at a time when pharmaceutical companies are …

Clinical pharmacogenomics: applications in pharmaceutical R&D

RM Norton - Drug discovery today, 2001 - Elsevier
Within the pharmaceutical industry, the application of clinical pharmacogenomics promises
to enhance the discovery of drug response markers, reduce the size and expense of clinical …

A pharmacogenomics primer

MH Court - The Journal of Clinical Pharmacology, 2007 - Wiley Online Library
The human genome project and related research initiatives have enabled the identification
of a significant number of genetic variants that are predictive of drug response and outcome …

[HTML][HTML] Pharmacogenomics in practice

L Wang, R Weinshilboum - Clinical pharmacology and …, 2019 - ncbi.nlm.nih.gov
Pharmacogenomics is an important aspect of clinical genomics that is touching an
increasingly large number of patients. That is because pharmacogenomic testing is being …

[HTML][HTML] Pharmacogenomic biomarkers for improved drug therapy—recent progress and future developments

VM Lauschke, L Milani, M Ingelman-Sundberg - The AAPS journal, 2018 - Springer
Much of the inter-individual variability in drug efficacy and risk of adverse reactions is due to
polymorphisms in genes encoding proteins involved in drug pharmacokinetics and …

Scientific challenges and implementation barriers to translation of pharmacogenomics in clinical practice

YWF Lam - International Scholarly Research Notices, 2013 - Wiley Online Library
The mapping of the human genome and subsequent advancements in genetic technology
had provided clinicians and scientists an understanding of the genetic basis of altered drug …

Pharmacogenetics at 50: genomic personalization comes of age

TJ Urban, DB Goldstein - Science translational medicine, 2014 - science.org
The study of the genetics of drug responses has a long history but has provided only a few
examples of gene variants that are relevant clinically. Here, we discuss the current state of …

A genomic “roadmap” to “better” drugs

G Liao, X Zhang, DJ Clark, G Peltz - Drug metabolism reviews, 2008 - Taylor & Francis
Utilization of pharmacogenomic information has the potential to significantly improve
treatment outcome and markedly reduce the rate of attrition of drugs in clinical development …

Pharmacogenetics and pharmacogenomics

JK Hicks, HL McLeod - Genomic and Precision Medicine, 2017 - Elsevier
Pharmacogenomics is a growing field of research that links genetic variation with drug
effects to determine impact on pharmacology and clinical application. Relationships …

Progress towards the integration of pharmacogenomics in practice

SD Mooney - Human genetics, 2015 - Springer
Understanding the role genes and genetic variants play in clinical treatment response
continues to be an active area of research with the goal of common clinical use. This goal …