Genetic predisposition to weight loss and regain with lifestyle intervention: analyses from the Diabetes Prevention Program and the Look AHEAD randomized …

GD Papandonatos, Q Pan, NM Pajewski… - Diabetes, 2015 - Am Diabetes Assoc
Clinically relevant weight loss is achievable through lifestyle modification, but unintentional
weight regain is common. We investigated whether recently discovered genetic variants …

Lifestyle interventions for weight control modified by genetic variation: a review of the evidence

PY Tan, SR Mitra, F Amini - Public Health Genomics, 2019 - karger.com
Abstract Background/Aims: Excess weight gain is a result of the interaction between diet,
environment, and genes. Evidence suggests that responses to lifestyle interventions to …

Genetic variation of fasting glucose and changes in glycemia in response to 2-year weight-loss diet intervention: the POUNDS LOST trial

T Wang, T Huang, Y Zheng, J Rood, GA Bray… - International journal of …, 2016 - nature.com
Objective: Weight-loss intervention through diet modification has been widely used to
improve obesity-related hyperglycemia; however, little is known about whether genetic …

Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program

LM Delahanty, Q Pan, KA Jablonski, KE Watson… - Diabetes …, 2012 - Am Diabetes Assoc
OBJECTIVE We tested genetic associations with weight loss and weight regain in the
Diabetes Prevention Program, a randomized controlled trial of weight loss–inducing …

Does weight loss prognosis depend on genetic make‐up?

MJ Moreno‐Aliaga, JL Santos, A Marti… - Obesity …, 2005 - Wiley Online Library
The prevalence of obesity is rising throughout the world. Indeed, obesity has reached
epidemic proportions in many developed and transition countries. Obesity is a complex …

[HTML][HTML] Genetic susceptibility to diabetes and long-term improvement of insulin resistance and β cell function during weight loss: the Preventing Overweight Using …

T Huang, SH Ley, Y Zheng, T Wang, GA Bray… - The American Journal of …, 2016 - Elsevier
Background: Diet interventions have shown effectiveness in improving diabetes risk factors;
however, little is known about whether the effects of diet intervention are different according …

FTO predicts weight regain in the Look AHEAD clinical trial

JM McCaffery, GD Papandonatos… - International journal of …, 2013 - nature.com
Background: Genome-wide association studies have provided new insights into the genetic
factors that contribute to the development of obesity. We hypothesized that these genetic …

Genetic predictors of weight loss in overweight and obese subjects

I Lamiquiz-Moneo, R Mateo-Gallego, AM Bea… - Scientific reports, 2019 - nature.com
The aim of our study was to investigate a large cohort of overweight subjects consuming a
homogeneous diet to identify the genetic factors associated with weight loss that could be …

Lifestyle and genetics in obesity and type 2 diabetes

T Temelkova-Kurktschiev… - Experimental and clinical …, 2012 - thieme-connect.com
Obesity and type 2 diabetes mellitus are multifactorial health threats caused by a complex
interplay between genetic predisposition and the environment with dramatically increasing …

Abdominal obesity genetic variants predict waist circumference regain after weight loss

MR Christiansen, TO Kilpeläinen, JM McCaffery - Diabetes, 2023 - Am Diabetes Assoc
Although many individuals are able to achieve weight loss, maintaining this loss over time is
challenging. We aimed to study whether genetic predisposition to general or abdominal …