T-cells have to recognize peptides presented on MHC molecules to be activated and elicit
their effector functions. Several studies demonstrate that some peptides are more …

The identification of MHC class II restricted peptide epitopes is an important goal in
immunological research. A number of computational tools have been developed for this …

Peptides bind to MHC class II molecules with a defined periodicity such that the peptide-
flanking residues (PFRs) P-1 and P11, which lie outside the core binding sequence (P1 …

The cellular immune system screens peptides presented by host cells on MHC molecules to
assess if the cells are infected. In this study we examined whether the presented peptides …

T-cell recognition of peptide/major histocompatibility complex (MHC) is a prerequisite for
cellular immunity. Recently, there has been an influx of bioinformatics tools to facilitate the …

Major histocompatibility complex class II (MHC‐II) molecules are expressed on the surface
of professional antigen‐presenting cells where they display peptides to T helper cells, which …

Abstract Background Class II Major Histocompatibility Complex (MHC) molecules have an
open-ended binding groove which can accommodate peptides of varying lengths. Several …

Identification of MHC-binding peptides is a prerequisite in rational design of T-cell based
peptide vaccines. During the past decade a number of computational approaches have …

MHC class I molecules generally present peptides of eight to ten amino acids; however,
peptides of 11–14 residues can also elicit dominant cytotoxic T lymphocyte responses …

T cell immune responses are driven by the recognition of peptide antigens (T cell epitopes)
that are bound to major histocompatibility complex (MHC) molecules. T cell epitope …