[PDF][PDF] A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv (3)(q21; q26) by activating EVI1 expression
Chromosomal inversion between 3q21 and 3q26 results in high-risk acute myeloid leukemia
(AML). In this study, we identified a mechanism whereby a GATA2 distal hematopoietic …
(AML). In this study, we identified a mechanism whereby a GATA2 distal hematopoietic …
[PDF][PDF] A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia
Chromosomal rearrangements without gene fusions have been implicated in
leukemogenesis by causing deregulation of proto-oncogenes via relocation of cryptic …
leukemogenesis by causing deregulation of proto-oncogenes via relocation of cryptic …
The leukemia-associated gene MDS1/EVI1 is a new type of GATA-binding transactivator
J Soderholm, H Kobayashi, C Mathieu, JD Rowley… - Leukemia, 1997 - nature.com
EVI1, located at chromosome band 3q26, encodes a 1051 amino acid zinc finger protein
inappropriately expressed in the leukemic cells of 2–5% of acute myeloid leukemia (AML) …
inappropriately expressed in the leukemic cells of 2–5% of acute myeloid leukemia (AML) …
Atypical 3q26/MECOM rearrangements genocopy inv(3)/t(3;3) in acute myeloid leukemia
S Ottema, R Mulet-Lazaro, HB Beverloo… - Blood, The Journal …, 2020 - ashpublications.org
Acute myeloid leukemia (AML) with inv (3)/t (3; 3)(q21q26) is a distinct World Health
Organization recognized entity, characterized by its aggressive course and poor prognosis …
Organization recognized entity, characterized by its aggressive course and poor prognosis …
Selective requirement of MYB for oncogenic hyperactivation of a translocated enhancer in leukemia
L Smeenk, S Ottema, R Mulet-Lazaro, A Ebert… - Cancer discovery, 2021 - AACR
In acute myeloid leukemia (AML) with inv (3)(q21; q26) or t (3; 3)(q21; q26), a translocated
GATA2 enhancer drives oncogenic expression of EVI1. We generated an EVI1-GFP AML …
GATA2 enhancer drives oncogenic expression of EVI1. We generated an EVI1-GFP AML …
Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA‐2 expression
H Yuasa, Y Oike, A Iwama, I Nishikata… - The EMBO …, 2005 - embopress.org
The ecotropic viral integration site‐1 (Evi1) is an oncogenic transcription factor in murine
and human myeloid leukemia. We herein show that Evi1 is predominantly expressed in …
and human myeloid leukemia. We herein show that Evi1 is predominantly expressed in …
[HTML][HTML] The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops
S Ottema, R Mulet-Lazaro… - Nature …, 2021 - nature.com
Chromosomal rearrangements are a frequent cause of oncogene deregulation in human
malignancies. Overexpression of EVI1 is found in a subgroup of acute myeloid leukemia …
malignancies. Overexpression of EVI1 is found in a subgroup of acute myeloid leukemia …
Aberrant EVI1 expression in acute myeloid leukaemia
AA Hinai, PJM Valk - British journal of haematology, 2016 - Wiley Online Library
Deregulated expression of the ecotropic virus integration site 1 (EVI 1) gene is the molecular
hallmark of therapy‐resistant myeloid malignancies bearing chromosomal inv (3)(q21q26· 2) …
hallmark of therapy‐resistant myeloid malignancies bearing chromosomal inv (3)(q21q26· 2) …
Cis-regulatory mechanisms governing stem and progenitor cell transitions
Cis-element encyclopedias provide information on phenotypic diversity and disease
mechanisms. Although cis-element polymorphisms and mutations are instructive …
mechanisms. Although cis-element polymorphisms and mutations are instructive …
EVI1 is critical for the pathogenesis of a subset of MLL-AF9–rearranged AMLs
EMJ Bindels, M Havermans, S Lugthart… - Blood, The Journal …, 2012 - ashpublications.org
The proto-oncogene EVI1 (ecotropic viral integration site-1), located on chromosome band
3q26, is aberrantly expressed in human acute myeloid leukemia (AML) with 3q26 …
3q26, is aberrantly expressed in human acute myeloid leukemia (AML) with 3q26 …