Abstract The AML1/EVI-1 chimeric gene is generated by the t (3; 21)(q26; q22) translocation
and plays a pivotal role in progression of hematopoietic stem cell malignancies such as …

There are many examples of transcription factor families whose members control gene
expression profiles of diverse cell types. However, the mechanism by which closely related …

Oncogene-mediated transformation of hematopoietic cells has been studied extensively, but
little is known about the molecular basis for restriction of oncogenes to certain target cells …

Overexpression of the ecotropic virus integration-1 (EVI1) gene (EVI1+), localized at
chromosome 3q26, is associated with adverse outcome in adult acute myeloid leukemia …

Myelodysplasia is a hematological disease in which genomic abnormalities accumulate in a
hematopoietic stem cell leading to severe pancytopenia, multilineage differentiation …

Ecotropic viral integration site-1 (Evi-1) is a nuclear transcription factor that plays an
essential role in the regulation of hematopoietic stem cells. Aberrant expression of Evi-1 has …

Knowledge of the key transcription factors that drive hematopoietic stem cell (HSC)
generation is of particular importance for current hematopoietic regenerative approaches …

Therapy-related myelodysplastic syndrome and acute myeloid leukemia (t-MDS/t-AML) are
late complications of cytotoxic therapy used in the treatment of malignant diseases. The most …

The EVI1 oncogene at human chr 3q26 is rearranged and/or overexpressed in a subset of
acute myeloid leukemias and myelodysplasias. The EVI1 protein is a 135 kDa …

The ecotropic viral integration site 1 (EVI1) gene was identified almost 20 years ago as the
integration site of an ecotropic retrovirus leading to murine myeloid leukemia. Since its …