Definitions of resistant and refractory cytomegalovirus infection and disease in transplant recipients for use in clinical trials

RF Chemaly, S Chou, H Einsele… - Clinical Infectious …, 2019 - academic.oup.com
Despite advances in preventive strategies, cytomegalovirus (CMV) infection remains a major
complication in solid organ and hematopoietic cell transplant recipients. CMV infection may …

Resistant or refractory cytomegalovirus infections after hematopoietic cell transplantation: diagnosis and management

F Khawaja, MV Batista, L El Haddad… - Current opinion in …, 2019 - journals.lww.com
Many advances have been made to optimize future clinical trials for management of
refractory or resistant CMV infections, and to better understand new resistance mechanisms …

Ganciclovir-resistant cytomegalovirus disease after allogeneic stem cell transplantation: pitfalls of phenotypic diagnosis by in vitro selection of an UL97 mutant strain

K Hamprecht, T Eckle, L Prix, C Faul… - The Journal of …, 2003 - academic.oup.com
A 9-month posttransplantation course of an allogeneic stem-cell transplant recipient (human
cytomegalovirus [HCMV] serostatus, donor positive/recipient negative), in whom ganciclovir …

Management of multidrug-resistant CMV infection in immunocompromised patients: case report of a heart-transplant recipient and review of the literature

C Deback, S Burrel, S Varnous, G Carcelain… - Antiviral …, 2015 - journals.sagepub.com
Cytomegalovirus (CMV) remains a leading cause of morbidity after solid organ
transplantation. The efficiency of antivirals for the treatment of CMV infections may be …

Genotypic resistance of cytomegalovirus to antivirals in hematopoietic stem cell transplant recipients from Portugal: A retrospective study

AB Campos, J Ribeiro, CP Vaz, F Campilho, R Branca… - Antiviral research, 2017 - Elsevier
The aim of this study was to characterize Human Cytomegalovirus (HCMV) drug resistance
mutations in UL97 and UL54 genes in allogeneic hematopoietic stem cell transplant (allo …

Update in management of ganciclovir-resistant cytomegalovirus infection

RK Avery - Current opinion in infectious diseases, 2008 - journals.lww.com
Antiviral-resistant cytomegalovirus infection remains a feared complication of transplantation
but is less frequently seen in AIDS patients in the current era. New research on resistance …

Antiviral drug resistance in human cytomegalovirus

S Chou - Transplant infectious disease, 1999 - Wiley Online Library
Drug‐resistant cytomegalovirus (CMV) should be considered when viral shedding persists
after several weeks of therapy. The problem is most likely to arise in the setting of a severely …

Double resistance to ganciclovir and foscarnet of four human cytomegalovirus strains recovered from AIDS patients

A Sarasini, F Baldanti, M Furione… - Journal of medical …, 1995 - Wiley Online Library
Four human cytomegalovirus (HCMV) isolates from four different AIDS patients treated with
both ganciclovir and foscarnet and not responding clinically to antiviral treatment, were …

How I treat resistant cytomegalovirus infection in hematopoietic cell transplantation recipients

F El Chaer, DP Shah… - Blood, The Journal of the …, 2016 - ashpublications.org
Cytomegalovirus (CMV) infection is a significant complication in hematopoietic cell
transplantation (HCT) recipients. Four antiviral drugs are used for preventing or treating …

Use of the human cytomegalovirus (HCMV) antigenemia assay for diagnosis and monitoring of HCMV infections and detection of antiviral drug resistance in the …

F Baldanti, MG Revello, E Percivalle, G Gerna - Journal of clinical virology, 1998 - Elsevier
Background: Quantification of viral load in blood has proven to be helpful in the follow-up of
disseminated HCMV infections in immunocompromised patients. Objectives:(i) To describe …