[HTML][HTML] Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology

LJ Howe, MK Lee, GC Sharp, G Davey Smith… - PLoS …, 2018 - journals.plos.org
There is increasing evidence that genetic risk variants for non-syndromic cleft lip/palate
(nsCL/P) are also associated with normal-range variation in facial morphology. However …

[HTML][HTML] Six NSCL/P loci show associations with normal-range craniofacial variation

K Indencleef, J Roosenboom, H Hoskens… - Frontiers in …, 2018 - frontiersin.org
Objectives: Orofacial clefting is one of the most prevalent craniofacial malformations.
Previous research has demonstrated that unaffected relatives of patients with non-syndromic …

[HTML][HTML] The intersection of the genetic architectures of orofacial clefts and normal facial variation

K Indencleef, H Hoskens, MK Lee, JD White… - Frontiers in …, 2021 - frontiersin.org
Unaffected relatives of individuals with non-syndromic cleft lip with or without cleft palate
(NSCL/P) show distinctive facial features. The presence of this facial endophenotype is …

Imputation of orofacial clefting data identifies novel risk loci and sheds light on the genetic background of cleft lip±cleft palate and cleft palate only

KU Ludwig, AC Böhmer, J Bowes… - Human molecular …, 2017 - academic.oup.com
Nonsyndromic cleft lip with or without cleft palate (nsCL/P) is among the most common
human birth defects with multifactorial etiology. Here, we present results from a genome …

[HTML][HTML] Genetic inheritance models of non-syndromic cleft lip with or without palate: from monogenic to polygenic

X Cheng, F Du, X Long, J Huang - Genes, 2023 - mdpi.com
Non-syndromic cleft lip with or without palate (NSCL/P) is a prevalent birth defect that affects
1/500–1/1400 live births globally. The genetic basis of NSCL/P is intricate and involves both …

[HTML][HTML] Non-syndromic cleft lip and palate polymorphisms affect normal lip morphology

C Wilson-Nagrani, S Richmond, L Paternoster - Frontiers in genetics, 2018 - frontiersin.org
Non-syndromic cleft lip with or without palate (NSCL/P) is a frequent malformation of the
facial region. Genetic variants (SNPs) within nineteen loci have been previously associated …

Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci

KU Ludwig, E Mangold, S Herms, S Nowak, H Reutter… - Nature …, 2012 - nature.com
We have conducted the first meta-analyses for nonsyndromic cleft lip with or without cleft
palate (NSCL/P) using data from the two largest genome-wide association studies published …

[HTML][HTML] Integrative approaches generate insights into the architecture of non-syndromic cleft lip with or without cleft palate

J Welzenbach, NL Hammond, M Nikolić… - Human Genetics and …, 2021 - cell.com
Non-syndromic cleft lip with or without cleft palate (nsCL/P) is a common congenital facial
malformation with a multifactorial etiology. Genome-wide association studies (GWASs) have …

[HTML][HTML] Genetic determination of human facial morphology: links between cleft-lips and normal variation

S Boehringer, F Van Der Lijn, F Liu… - European Journal of …, 2011 - nature.com
Recent genome-wide association studies have identified single nucleotide polymorphisms
(SNPs) associated with non-syndromic cleft lip with or without cleft palate (NSCL/P), and …

Genome-wide analyses identify a novel risk locus for nonsyndromic cleft palate

M He, X Zuo, H Liu, W Wang, Y Zhang… - Journal of Dental …, 2020 - journals.sagepub.com
The 3 major subphenotypes observed in patients with nonsyndromic orofacial clefts
(NSOFCs) are nonsyndromic cleft lip only (NSCLO), nonsyndromic cleft lip with palate …