Cardiomyocyte proliferation and progenitor differentiation are endogenous mechanisms of
myocardial development. Cardiomyocytes continue to proliferate in mammals for part of post …

The adult mammalian heart is incapable of clinically relevant regeneration. The regenerative
deficit in adult mammalian heart contrasts with the fetal and neonatal heart, which …

Abstract Purpose of Review Current pharmacologic treatments for cardiovascular disease
do not correct the underlying cellular defect, the loss of cardiomyocytes. With recent …

Cell-based therapies hold promise of repairing an injured heart, and the description of stem
and progenitor cells with cardiomyogenic potential is critical to its realization. At the …

▪ Abstract Many forms of pediatric and adult heart disease result from a deficiency in
cardiomyocyte number. Through repopulation of the heart with new cardiomyocytes (that is …

Heart failure is a major source of morbidity and mortality. Replacing lost myocardium with
new tissue is a major goal of regenerative medicine. Unlike adult mammals, zebrafish and …

The newt and the zebrafish have the ability to regenerate many of their tissues and organs
including the heart. Thus, a major goal in experimental medicine is to elucidate the …

Cardiac myocytes rapidly proliferate during fetal life but exit the cell cycle soon after birth in
mammals. Although the extent to which adult cardiac myocytes are capable of cell cycle …

Cardiac regeneration strategies and de novo generation of cardiomyocytes have long been
significant areas of research interest in cardiovascular medicine. In this review, we outline a …

The role and even the existence of new myocyte formation in the adult heart remain
controversial. Documentation of cell cycle regulators, deoxyribonucleic acid synthesis, and …