The interleukin‐15/interleukin‐15 receptor system as a model for juxtacrine and reverse signaling
S Bulfone‐Paus, E Bulanova, V Budagian, R Paus - Bioessays, 2006 - Wiley Online Library
Abstract Interleukin‐15 (IL‐15) is a pleiotropic cytokine of the 4 α‐helix bundle family, which
binds to a receptor complex that displays common elements with the IL‐2 receptor and a …
binds to a receptor complex that displays common elements with the IL‐2 receptor and a …
Novel insights into interleukin 6 (IL-6) cis-and trans-signaling pathways by differentially manipulating the assembly of the IL-6 signaling complex
M Lacroix, F Rousseau, F Guilhot, P Malinge… - Journal of Biological …, 2015 - ASBMB
The IL-6 signaling complex is described as a hexamer, formed by the association of two IL-6·
IL-6 receptor (IL-6R)· gp130 trimers, with gp130 being the signal transducer inducing cis …
IL-6 receptor (IL-6R)· gp130 trimers, with gp130 being the signal transducer inducing cis …
Reverse signaling through membrane-bound interleukin-15
V Budagian, E Bulanova, Z Orinska, T Pohl… - Journal of Biological …, 2004 - ASBMB
The results from this study implicate membrane-anchored interleukin (IL)-15 constitutively
expressed on the cell surface of PC-3 human prostate carcinoma cells and interferon-γ …
expressed on the cell surface of PC-3 human prostate carcinoma cells and interferon-γ …
IL-15/IL-15 receptor biology: a guided tour through an expanding universe
V Budagian, E Bulanova, R Paus… - Cytokine & growth factor …, 2006 - Elsevier
The cytokine interleukin-15 (IL-15) has a key role in promoting survival, proliferation and
activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL …
activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL …
[HTML][HTML] Identification and functional characterization of a second chain of the interleukin‐10 receptor complex
SV Kotenko, CD Krause, LS Izotova, BP Pollack… - The EMBO …, 1997 - embopress.org
Abstract Interleukin‐10 (IL‐10) is a pleiotropic cytokine which signals through a specific cell
surface receptor complex. Only one chain, that for ligand binding (IL‐10Rα or IL‐10R1), was …
surface receptor complex. Only one chain, that for ligand binding (IL‐10Rα or IL‐10R1), was …
Generation of soluble interleukin‐11 and interleukin‐6 receptors: a crucial function for proteases during inflammation
The cytokines interleukin‐11 (IL‐11) and IL‐6 are important proteins with well‐defined pro‐
and anti‐inflammatory functions. They activate intracellular signaling cascades through a …
and anti‐inflammatory functions. They activate intracellular signaling cascades through a …
[HTML][HTML] Recent advances in understanding the role of IL-4 signaling
Abstract Interleukin-4 (IL-4) is a four-α-helical bundle type I cytokine with broad pleiotropic
actions on multiple lineages. Major actions of IL-4 were initially discovered for B and T cells …
actions on multiple lineages. Major actions of IL-4 were initially discovered for B and T cells …
The roles of interleukin-15 receptor α: Trans-presentation, receptor component, or both?
KS Schluns, T Stoklasek, L Lefrançois - The international journal of …, 2005 - Elsevier
Interleukin-15 receptor α (IL-15Rα) is a high affinity IL-15 binding protein that is crucial for
mediating IL-15 functions such as memory CD8 T cell proliferation and NK, NK/T cell, and …
mediating IL-15 functions such as memory CD8 T cell proliferation and NK, NK/T cell, and …
Structural understanding of interleukin 6 family cytokine signaling and targeted therapies: focus on interleukin 11
Cytokines are small signaling proteins that have central roles in inflammation and cell
survival. In the half-century since the discovery of the first cytokines, the interferons, over fifty …
survival. In the half-century since the discovery of the first cytokines, the interferons, over fifty …
Crystal structure of the interleukin-15· interleukin-15 receptor α complex: insights into trans and cis presentation
Interleukin (IL)-15 is a pleiotropic cytokine that plays a pivotal role in both innate and
adaptive immunity. IL-15 is unique among cytokines due to its participation in a trans …
adaptive immunity. IL-15 is unique among cytokines due to its participation in a trans …