Abstract Interleukin‐15 (IL‐15) is a pleiotropic cytokine of the 4 α‐helix bundle family, which
binds to a receptor complex that displays common elements with the IL‐2 receptor and a …

The IL-6 signaling complex is described as a hexamer, formed by the association of two IL-6·
IL-6 receptor (IL-6R)· gp130 trimers, with gp130 being the signal transducer inducing cis …

The results from this study implicate membrane-anchored interleukin (IL)-15 constitutively
expressed on the cell surface of PC-3 human prostate carcinoma cells and interferon-γ …

The cytokine interleukin-15 (IL-15) has a key role in promoting survival, proliferation and
activation of natural killer (NK) and CD8+ T cells. Despite its functional similarities to IL-2, IL …

Abstract Interleukin‐10 (IL‐10) is a pleiotropic cytokine which signals through a specific cell
surface receptor complex. Only one chain, that for ligand binding (IL‐10Rα or IL‐10R1), was …

The cytokines interleukin‐11 (IL‐11) and IL‐6 are important proteins with well‐defined pro‐
and anti‐inflammatory functions. They activate intracellular signaling cascades through a …

Abstract Interleukin-4 (IL-4) is a four-α-helical bundle type I cytokine with broad pleiotropic
actions on multiple lineages. Major actions of IL-4 were initially discovered for B and T cells …

Interleukin-15 receptor α (IL-15Rα) is a high affinity IL-15 binding protein that is crucial for
mediating IL-15 functions such as memory CD8 T cell proliferation and NK, NK/T cell, and …

Cytokines are small signaling proteins that have central roles in inflammation and cell
survival. In the half-century since the discovery of the first cytokines, the interferons, over fifty …

Interleukin (IL)-15 is a pleiotropic cytokine that plays a pivotal role in both innate and
adaptive immunity. IL-15 is unique among cytokines due to its participation in a trans …