In this study, EGFR-activating mutation status and DNA copy number abundances of
members of ErbB family were measured in 261 lung adenocarcinomas. The associations …

Background: Positive expression of estrogen receptor (ER) beta is correlated with a
favorable prognosis for patients with epidermal growth factor receptor (EGFR) mutations and …

Background This study was designed to investigate EGFR protein expression, EGFR copy
number and EGFR mutations in lung adenocarcinomas, to explore the relationship of the …

Introduction Unlike common EGFR mutations, many less common EGFR mutations remain
poorly characterized in terms of oncogenic function and drug sensitivity. Here, we …

INTRODUCTION: Mutations in the tyrosine kinase domain of the epidermal growth factor
receptor (EGFR) are frequently detected in lung adenocarcinomas with bronchioloalveolar …

Introduction Inherited genetic determinants of lung cancer risk remain relatively elusive.
Germline mutations in EGFR and erb-b2 receptor tyrosine kinase 2 (ERBB2) have been …

Background Data from studies looking at both EGFR and ERBB2 exon 20 insertion
mutations (-20ins) in the same cohort of patients with non-small cell lung cancer (NSCLC) …

Background Lung cancer often exhibits molecular changes, such as the overexpression of
the ErbB1 gene. ErbB1 encodes epidermal growth factor receptor (EGFR), a tyrosine kinase …

The present study assessed whether estrogen receptor (ER) β1 is associated with the
survival of patients with advanced lung adenocarcinoma, with or without mutations of the …

BACKGROUND Much evidence has accumulated that the epidermal growth factor receptor
(EGFR) and its family members are strongly implicated in the development and progression …