Degradation of extracellular matrix chondroitin sulphate proteoglycans (CSPGs) using
Chondroitinase ABC (ChABC) is a promising strategy for the treatment of spinal cord injury …

Background: Chondroitin sulfate glycosaminoglycans (CS-GAGs) are the primary inhibitory
GAGs for neuronal growth after central nervous system (CNS) injury. However, the inhibitory …

In the present study we tested whether N-acetyl-L-cysteine (LNAC) affects apoptotic death of
neuronal cells caused by trophic factor deprivation. LNAC, an antioxidant, elevates …

Chondroitin sulphate proteoglycan (CSPG) inhibits axonal regeneration in the central
nervous system (CNS) and its local degradation promotes repair. We postulated that the …

Adjacent astrocytes in the grey matter of the mammalian cerebral cortex are organized in a
tile-like manner and separated from one another, forming discrete domains named “non …

Publisher Summary This chapter focuses on the changes in the expression of the axon
growth-inhibitory chondroitin sulphate proteoglycans (CSPGs). CSPGs represent a varied …

Chondroitin sulfate proteoglycans (CSPGs) represent a major barrier to regenerating axons
in the central nervous system (CNS), but the structural diversity of their polysaccharides has …

Increased chondroitin sulfate proteoglycan (CSPG) expression in the vicinity of a spinal cord
injury (SCI) is a primary participant in axonal regeneration failure. However, the presence of …

Perineuronal nets (PNNs) are extracellular matrix (ECM) structures that enmesh and
regulate neurocircuits involved in motor and sensory function. Maladaptive changes to the …

Axons in the peripheral nervous system can regenerate after injury, whereas axons in the
central nervous system (CNS) do not readily regenerate. Intrinsic regenerating capacity and …