Context: As in many other human cancers, overactivation of the phosphotidylinositol 3-
kinase (PI3K)/Akt signaling pathway occurs frequently in thyroid cancer, but the mechanism …

Context: Genetic aberration in phosphatidylinositol 3-kinase (PI3K)/AKT pathway has been
detected in numerous and diverse human cancers. PIK3CA, which encodes for the catalytic …

Genetic alterations in the PIK3CA gene of the phosphoinositide 3-kinase (PI3K)/AKT
pathway have been found in many human tumors, but they have not been explored in …

Abstract The phosphatidylinositol 3′-kinase (PI3K) pathway is frequently activated in
thyroid carcinomas through the constitutive activation of stimulatory molecules (eg, Ras) …

Purpose: To investigate the overall occurrence and relationship of genetic alterations in the
phosphatidylinositol 3-kinase (PI3K)/Akt pathway in thyroid tumors and explore the scope of …

Context: Genetic alterations in the phosphatidylinositol-3-kinase (PI3K)/Akt pathway and
their role in thyroid tumor pathogenesis in Chinese people remain undefined. Objective: The …

Purpose: Recent studies have reported high frequencies of somatic mutations in the
phosphoinositide-3-kinase catalytic α (PIK3CA) gene in several human solid tumors …

Purpose: Activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway, resulting in
increased cell proliferation, survival, and motility, is believed to play an oncogenic role in …

The phosphatidylinositol 3-kinase (PI3K) signaling pathway is an important regulator of
many cellular events, including apoptosis, proliferation, and motility. Enhanced activation of …

Phosphatidylinositol 3-kinases (PI3Ks) are important regulators of signaling pathways. To
determine whether PI3Ks are genetically altered in human cancers, we recently analyzed …