High-throughput metabolic profiling, known as metabolomics1 or metabonomics2, has been
an active area of research for over 35 years3. The most commonly employed analytical …

The concept of metabolite profiling has been around for decades, but technical innovations
are now enabling it to be carried out on a large scale with respect to the number of both …

Identification of unknown metabolites is a major challenge in metabolomics. Without the
identities of the metabolites, the metabolome data generated from a biological sample …

We compared the performance of gas chromatography time-of-flight mass spectrometry (GC-
MS) and comprehensive two-dimensional gas chromatography mass spectrometry (GC× GC …

Mass spectrometry (MS) has secured a central role in metabolomics that is predicted to grow
based upon continuous developments and improvements in MS technologies. This article …

We developed a new software program, MRMPROBS, for widely targeted metabolomics by
using the large-scale multiple reaction monitoring (MRM) mode. The strategy became …