Substantial evidence supports the oncogenic role of the E3 ubiquitin ligase S-phase kinase-
associated protein 2 (Skp2) in many types of cancers through its ability to target a broad …

1. ABSTRACT E3 ubiquitin ligase Skp2 attaches ubiquitin to its target proteins and marks
them for destruction by the 26S proteasome. This mechanism participates in a number of …

The RB1 tumor suppressor gene is mutated in highly aggressive tumors including small-cell
lung cancer (SCLC), where its loss, along with TP53, is required and sufficient for …

SKP2, an F-box protein of the SCF type of the E3 ubiquitin ligase complex, plays an
important function in driving tumorigenesis through the destruction of numerous tumor …

Skp1 overexpression promotes tumor growth, whereas reduced Skp1 activity is also linked
with genomic instability and neoplastic transformation. This highlights the need to gain better …

Proteins that regulate the cell cycle are accumulated and degraded in a coordinated manner
during the transition from one cell cycle phase to the next. The rapid loss of a critical protein …

Strictly regulated protein degradation by ubiquitin-proteasome system (UPS) is essential for
various cellular processes whose dysregulation is linked to serious diseases including …

Skp2 E3 ligase is overexpressed in numerous human cancers and plays a critical role in cell-
cycle progression, senescence, metabolism, cancer progression, and metastasis. In the …

The dysregulation of pathways regulat-ing cellular function is a frequent hallmark of cancer
and the development of specific pathway inhibitors that alter tumor growth and progression …

S-phase kinase-associated protein 2 (Skp2) is a substrate-specific adaptor in Skp1-CUL1-
ROC1-F-box E3 ubiquitin ligases and widely regarded as an oncogene. Therefore, Skp2 …