Aims The prognostic value of genetic variants for predicting lethal arrhythmic events (LAEs)
in Brugada syndrome (BrS) remains controversial. We investigated whether the functional …

Cardiomyocytes derived from induced pluripotent stem cells (iPSC-CMs) offer an attractive
platform for cardiovascular research. Patient-specific iPSC-CMs are very useful for studying …

Background: BrS is an inherited sudden cardiac death syndrome. Less than 35% of BrS
probands have genetically identified pathogenic variants. Recent evidence has implicated …

BACKGROUND: The Brugada syndrome is an inherited cardiac electrical disorder
associated with a high incidence of life-threatening arrhythmias. Screening for mutations in …

Brugada Syndrome (BrS) is a genetic heart condition linked to sudden cardiac death.
Though the SCN5A gene is primarily associated with BrS, there is a lack of comprehensive …

Abstract Background Brugada syndrome (BrS) is an inherited arrhythmic disease linked to
SCN5A mutations. It is controversial whether SCN5A mutation carriers possess a greater …

Brugada syndrome (BrS) is a known cause of sudden cardiac death. The genetic basis of
BrS is not well understood, and no one single gene is linked to even a majority of BrS cases …

Background SCN5A mutations are associated with multiple arrhythmic and cardiomyopathic
phenotypes including Brugada syndrome (BrS), sinus node dysfunction (SND) …

Background Loss-of-function mutations in SCN5A are associated in∼ 20% of Brugada
syndrome (BrS) patients. Copy number variations (CNVs) have been shown to be …

Background: Inherited loss of function mutations in SCN5A have been linked to overlapping
syndromes including cardiac conduction disease and Brugada syndrome (BrS). The …