Background The high heritability of adiposity combined with its shifting distribution over time
suggests that genetic and environmental influences interact in the etiology of adiposity …

There is considerable evidence for both environmental and genetic causes of obesity.
Increased availability of cheap, palatable food plays a role, but despite the ubiquity of the …

Background: The behavioral susceptibility model proposes that inherited differences in traits
such as appetite confer differential risk of weight gain and contribute to the heritability of …

An obesigenic environment is a potent force for promoting weight gain. However, not all
people exposed to such an environment become obese; some remain lean. This means that …

Background: The modern environment is ubiquitously 'obesogenic', yet people vary
enormously in weight. One factor contributing to weight variation could be genetically …

Abstract Purpose of Review There is considerable variability in human body weight, despite
the ubiquity of the 'obesogenic'environment. Human body weight has a strong genetic basis …

Obesity is a global and growing problem. The detrimental health consequences of obesity
are significant and include co-morbidities such as diabetes, cancer and coronary heart …

The sudden onset of the obesity epidemic in high-income countries at the end of the last
century coincided with major changes to the food supply, resulting in larger portion sizes …

Why do some people remain lean while others are susceptible to obesity, and why do obese
individuals vary in their successes in losing weight? Despite physiological processes that …

Background Many genetic variants show highly robust associations with body mass index
(BMI). However, the mechanisms through which genetic susceptibility to obesity operates …