Introduction: One of the possibilities for reducing the emergence and spread of antibiotic
resistance is the use of anti-resistance compounds capable of resensitizing resistant …

Resistance to multiple drugs in medically important bacteria results in therapeutic
challenges for the clinician. The mechanisms by which bacteria evade the effects of …

The increasing multi-drug resistance has become a major threat to the public health.
Overexpression of multidrug efflux pumps is one of the major mechanisms of drug resistance …

Efflux mechanisms have become broadly recognized as major components of resistance to
many classes of antibiotics. Some efflux pumps selectively extrude specific antibiotics, while …

The potential for the build-up of resistance to a particular antibiotic endangers its therapeutic
application over time. In recent decades, antibiotic resistance has become one of the most …

The rapid spread of bacteria expressing multidrug resistance (MDR) has necessitated the
discovery of new antibacterials and resistance-modifying agents. Since the initial discovery …

The emergence of active efflux as a major causative factor in antibiotic resistance has been
one of the most significant trends in antiinfective chemotherapy over the last decade. The …

The world of antibiotic drug discovery and development is driven by the necessity to
overcome antibiotic resistance in common Gram-positive and Gram-negative pathogens …

Antimicrobial resistance (AMR) has become a major problem in public health leading to an
estimated 4.95 million deaths in 2019. The selective pressure caused by the massive and …

It is now well established that bacterial resistance to antibiotics has become a serious
problem of public health that concerns almost all antibacterial agents and that manifests in …