Summary Type I interferons (IFN-Is) are fundamental for antiviral immunity, but their role in
bacterial infections is contradictory and incompletely described. Streptococcus pyogenes …

Type I interferon (IFN-I) signaling paradoxically impairs host immune responses during
many primary and secondary bacterial infections. Lack of IFN-I receptor reduces bacterial …

Although type I interferons (IFN-I) were initially defined as potent antiviral agents, they can
also cause decreased host resistance to some bacterial and viral infections. The many …

Numerous bacterial products such as lipopolysaccharide potently induce type I interferons
(IFNs); however, the contribution of this innate response to host defense against bacterial …

Host control of influenza A virus (IAV) is associated with exuberant pulmonary inflammation
characterized by the influx of myeloid cells and production of proinflammatory cytokines …

Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes: Cell Skip
to Main Content Advertisement Cell This journal offers authors two options (open access or …

Type III interferons (IFNs) or the lambda IFNs (IFNLs or IFN-λs) are antimicrobial cytokines
that play key roles in immune host defense at endothelial and epithelial barriers. IFNLs …

Interferons (IFNs) were discovered over a half-century ago as antiviral factors. The role of
type I IFNs has been studied in the pathogenesis of both acute and chronic microbial …

Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …

Defense against bacterial infections requires activation of the immune response as well as
timely reestablishment of tissue and immune homeostasis. Instauration of homeostasis is …