NO and its derivatives can have multiple effects, which impact on neuronal death in different
ways. High levels of NO induces energy depletion-induced necrosis, due to:(i) rapid …

In inflammatory, infectious, ischemic, and neurodegenerative pathologies of th central
nervous system (CNS) glia become “activated” by inflammatory mediators, and express new …

In this tribute to Solomon H. Snyder (Sol) we discuss the mechanisms by which nitric oxide
(NO) kills neurons. We provide a historical perspective regarding the discovery that …

Nitric oxide (NO) has several essential roles in mammals, but unregulated NO production
can cause cell death through oxidative stress, disrupted energy metabolism, DNA damage …

NO or its derivatives (reactive nitrogen species: RNS) have three types of actions on
mitochondria: 1) reversible inhibition of mitochondrial respiration at cytochrome oxidase by …

Nitric oxide (NO) is an important bioregulatory molecule in the nervous, immune and
cardiovascular systems. NO participates in the regulation of the daily activities of cells as …

Nitric oxide (NO) and zinc (Zn 2+) are implicated in the pathogenesis of cerebral ischemia
and neurodegenerative diseases. However, their relationship and the molecular mechanism …

NO or its derivatives (reactive nitrogen species: RNS) inhibit mitochondrial respiration in two
different ways:(i) an acute, potent, and reversible inhibition of cytochrome oxidase by NO in …

The role of the neural messenger nitric oxide (NO) in cerebral ischaemia has been
investigated extensively in the past decade. NO may play either a protective or destructive …

Nitric oxide (NO) produced by the constitutive NO synthase (cNOS) in neurons has been
implicated in mediating excitotoxic neuronal death. In our murine cortical cell culture system …