Lp (a) concentrations are controlled primarily by genetic variation at LPA, the locus encoding
the unique protein apo (a). However, the high heritability is in part a consequence of nearly …

Abnormal fatty acid metabolism and availability are landmarks of metabolic diseases, which
in turn are associated with aberrant DNA methylation profiles. To understand the role of fatty …

Background DNA methylation is a dynamic epigenetic mechanism that occurs at cytosine-
phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS) …

Background Familial hypercholesterolemia (FH) is a monogenic disorder characterized by
elevated low-density lipoprotein cholesterol (LDL-C). A FH causing genetic variant in LDLR …

Background The link between DNA methylation, obesity, and adiposity-related diseases in
the general population remains uncertain. Methods and Findings We conducted an …

Rationale: Previous EWASs (Epigenome-Wide Association Studies) suggest that obesity
may be the cause, not a consequence, of changes in DNA methylation (DNAm). However …

Background Tobacco smoking, a risk factor for coronary artery disease (CAD), is known to
modify DNA methylation. We hypothesized that tobacco smoking modifies methylation of the …

Background Elevated serum homocysteine is associated with an increased risk of
cardiovascular disease (CVD). This may reflect a reduced systemic remethylation capacity …

Background: DNA methylation patterns associated with habitual diet have not been well
studied. Methods: Diet quality was characterized using a Mediterranean-style diet score and …

Expression quantitative trait methylation (eQTM) analysis identifies DNA CpG sites at which
methylation is associated with gene expression. The present study describes an eQTM …