Combinatorial strategies for cell transplantation in traumatic spinal cord injury

V Jagrit, J Koffler, JN Dulin - Frontiers in Neuroscience, 2024 - frontiersin.org
Spinal cord injury (SCI) substantially reduces the quality of life of affected individuals.
Recovery of function is therefore a primary concern of the patient population and a primary …

Incorporating combinatorial approaches to encourage targeted neural stem/progenitor cell integration following transplantation in spinal cord injury

K Pieczonka, MG Fehlings - Stem Cells Translational Medicine, 2023 - academic.oup.com
Spinal cord injury (SCI) severely diminishes quality of life and presents patients with a
substantial financial burden. The lack of a curative treatment has guided efforts toward …

Neural stem cell therapies for spinal cord injury repair: an update on recent preclinical and clinical advances

SM Hosseini, B Borys, S Karimi-Abdolrezaee - Brain, 2024 - academic.oup.com
Traumatic spinal cord injury (SCI) is a leading cause of lifelong disabilities. Permanent
sensory, motor and autonomic impairments after SCI are substantially attributed to …

Stem cell-based combinatorial therapies for spinal cord injury: a narrative review of current research and future directions

N Aderinto, MO Abdulbasit… - Annals of Medicine and …, 2023 - journals.lww.com
Spinal cord injury (SCI) is a devastating condition that can result in lifelong disability.
Despite significant progress in SCI research, current treatments only offer limited functional …

[HTML][HTML] Biomaterial-supported cell transplantation treatments for spinal cord injury: challenges and perspectives

S Liu, T Schackel, N Weidner… - Frontiers in cellular …, 2018 - frontiersin.org
Spinal cord injury (SCI), resulting in para-and tetraplegia caused by the partial or complete
disruption of descending motor and ascending sensory neurons, represents a complex …

Stem cells for spinal cord injury: Strategies to inform differentiation and transplantation

NR Iyer, TS Wilems… - Biotechnology and …, 2017 - Wiley Online Library
The complex pathology of spinal cord injury (SCI), involving a cascade of secondary events
and the formation of inhibitory barriers, hampers regeneration across the lesion site and …

Transplanting neural progenitor cells to restore connectivity after spinal cord injury

I Fischer, JN Dulin, MA Lane - Nature Reviews Neuroscience, 2020 - nature.com
Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …

[HTML][HTML] Combinatorial strategies with Schwann cell transplantation to improve repair of the injured spinal cord

J Fortun, CE Hill, MB Bunge - Neuroscience letters, 2009 - ncbi.nlm.nih.gov
The immediate effect of spinal cord injury (SCI) is a mechanical trauma that results in direct
damage at the lesion site followed by secondary responses leading to loss of adjacent …

[HTML][HTML] Novel innovations in cell and gene therapies for spinal cord injury

MM Zavvarian, A Toossi, M Khazaei, J Hong… - …, 2020 - ncbi.nlm.nih.gov
Spinal cord injury (SCI) leads to chronic and multifaceted disability, which severely impacts
the physical and mental health as well as the socio-economic status of affected individuals …

Cellular transplantation-based evolving treatment options in spinal cord injury

M Wu, H Yuan, K Li, DL Qiu - Cell biochemistry and biophysics, 2015 - Springer
Spinal cord injury (SCI) often represents a condition of permanent neurologic deficit. It has
been possible to understand and delineate the mechanisms contributing to loss of function …