Role of the sixth transmembrane segment of domain IV of the cockroach sodium channel in the action of sodium channel blocker insecticides
KS Silver, Y Nomura, VL Salgado, K Dong - Neurotoxicology, 2009 - Elsevier
Sodium channel blocker insecticides (SCBIs), such as indoxacarb and metaflumizone, are a
new class of insecticides with a mechanism of action different from those of other …
new class of insecticides with a mechanism of action different from those of other …
Analysis of the action of lidocaine on insect sodium channels
W Song, KS Silver, Y Du, Z Liu, K Dong - Insect biochemistry and molecular …, 2011 - Elsevier
A new class of sodium channel blocker insecticides (SCBIs), which include indoxacarb, its
active metabolite, DCJW, and metaflumizone, preferably block inactivated states of both …
active metabolite, DCJW, and metaflumizone, preferably block inactivated states of both …
Mechanism of action of sodium channel blocker insecticides (SCBIs) on insect sodium channels
KS Silver, W Song, Y Nomura, VL Salgado… - Pesticide biochemistry …, 2010 - Elsevier
Sodium channel blocker insecticides (SCBIs) are a relatively new class of insecticides, with
a mechanism of action different from those of other classes of insecticides that target voltage …
a mechanism of action different from those of other classes of insecticides that target voltage …
Identification of a cluster of residues in transmembrane segment 6 of domain III of the cockroach sodium channel essential for the action of pyrethroid insecticides
Y Du, JE Lee, Y Nomura, T Zhang… - Biochemical …, 2009 - portlandpress.com
A phenylalanine residue (Phe1519) in the sixth transmembrane segment of domain III (IIIS6)
of the cockroach BgNav sodium channel is required for the binding and action of …
of the cockroach BgNav sodium channel is required for the binding and action of …
Role of the local anesthetic receptor in the state-dependent inhibition of voltage-gated sodium channels by the insecticide metaflumizone
RT von Stein, DM Soderlund - Molecular pharmacology, 2012 - ASPET
Sodium channel inhibitor (SCI) insecticides selectively target voltage-gated sodium (Nav)
channels in the slow-inactivated state by binding at or near the local anesthetic receptor …
channels in the slow-inactivated state by binding at or near the local anesthetic receptor …
Mutations in the transmembrane helix S6 of domain IV confer cockroach sodium channel resistance to sodium channel blocker insecticides and local anesthetics
Indoxacarb and metaflumizone are two sodium channel blocker insecticides (SCBIs). They
preferably bind to and trap sodium channels in the slow-inactivated non-conducting state, a …
preferably bind to and trap sodium channels in the slow-inactivated non-conducting state, a …
An alanine in segment 3 of domain III (IIIS3) of the cockroach sodium channel contributes to the low pyrethroid sensitivity of an alternative splice variant
Y Du, Z Liu, Y Nomura, B Khambay, K Dong - Insect biochemistry and …, 2006 - Elsevier
In a previous study, we showed that two alternative exons (G1 and G2 encoding IIIS3-S4)
were involved in the differential sensitivity of two cockroach sodium channel splice variants …
were involved in the differential sensitivity of two cockroach sodium channel splice variants …
A residue in the transmembrane segment 6 of domain I in insect and mammalian sodium channels regulate differential sensitivities to pyrethroid insecticides
EE Oliveira, Y Du, Y Nomura, K Dong - Neurotoxicology, 2013 - Elsevier
Voltage-gated sodium channels are critical for electrical signaling in the nervous system.
Pyrethroid insecticides exert their toxic action by modifying the gating of sodium channels. A …
Pyrethroid insecticides exert their toxic action by modifying the gating of sodium channels. A …
Indoxacarb, metaflumizone, and other sodium channel inhibitor insecticides: mechanism and site of action on mammalian voltage-gated sodium channels
RT von Stein, KS Silver, DM Soderlund - Pesticide biochemistry and …, 2013 - Elsevier
Sodium channel inhibitor (SCI) insecticides were discovered almost four decades ago but
have only recently yielded important commercial products (eg, indoxacarb and …
have only recently yielded important commercial products (eg, indoxacarb and …
[HTML][HTML] The receptor site and mechanism of action of sodium channel blocker insecticides
Y Zhang, Y Du, D Jiang, C Behnke, Y Nomura… - Journal of Biological …, 2016 - ASBMB
Sodium channels are excellent targets of both natural and synthetic insecticides with high
insect selectivity. Indoxacarb, its active metabolite DCJW, and metaflumizone (MFZ) belong …
insect selectivity. Indoxacarb, its active metabolite DCJW, and metaflumizone (MFZ) belong …
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