Cancer development is highly associated to the physiological state of the tumor
microenvironment (TME). Despite the existing heterogeneity of tumors from the same or from …

Cellular and stromal components including tumor cells, immune cells, mesenchymal cells,
cancer-linked fibroblasts, and extracellular matrix, constituent tumor microenvironment …

A bottleneck that is hindering therapeutics innovation in cancers is the current lack of
integration of what we have learned in tumor biology as well as the tumor microenvironment …

Tumors are highly heterogeneous at the patient, tissue, cellular, and molecular levels. This
multi-scale heterogeneity poses significant challenges for effective therapies, which ideally …

Genetic alterations drive tumor onset and progression. However, the cross‑talk between
tumor cells and the benign components of the surrounding stroma can also promote the …

Similarly to our healthy organs, the tumor tissue also constitutes an ecosystem. This implies
that stromal cells acquire an altered phenotype in tandem with tumor cells, thereby …

Tumorigenesis is a complex and dynamic process involving different cellular and non-
cellular elements composed of tumor microenvironment (TME). The interaction of TME with …

The tumour microenvironment (TME) plays a pivotal role in tumour fate determination. The
TME acts together with the genetic material of tumour cells to determine their initiation …

The “Tumor microenvironment”(TME) is a complex, interacting system of the tumor and its
surrounding environment. The TME has drawn more attention recently in attempts to …

Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …