Most toxic agents currently used for chemotherapy show a narrow therapeutic window,
because of their inability to distinguish between healthy and cancer cells. Targeted drug …

Targeted delivery of chemotherapeutics and diagnostic agents conjugated to carrier ligands
has made significant progress in recent years, both in regards to the structural design of the …

Cancer remains the leading cause of death worldwide despite advances in treatment
options for patients. As such, safe and effective therapeutics are required. Short peptides …

Drug delivery systems are generally believed to comprise drugs and excipients. A peptide–
drug conjugate is a single molecule that can simultaneously play multiple roles in a drug …

To establish efficient and reliable therapeutic delivery into cancer cells, a number of delivery
agents and concepts have been investigated in the recent years. Among many …

Cancer is the second leading cause of death affecting nearly one in two people, and the
appearance of new cases is projected to rise by> 70% by 2030. To effectively combat the …

Targeted drug delivery to specific group of cells offers an attractive strategy to minimize the
undesirable side effects and achieve the therapeutic effect with a lower dose. Both linear …

Important elements for an efficient tumor targeted delivery are cancer-specific de novo-or
over-expression of target receptors and their availability on the tumor cell surface. Peptides …

Functional peptides that are made up of diverse endogenous amino acids with a specific
sequence and length have shown various functionalities including specific biological …

The past decades witnessed an increasing interest in peptides as clinical therapeutics.
Rightfully considered as a potential alternative for small molecule therapy, these remarkable …