568a Wednesday, February 6, 2013 the long fiber axis while the b-strands run perpendicular
(cross-b) to the fiber axis. b-helices are a parallel b-sheet motif that have similar properties to …

Introduction: Sickle cell disease is characterized by a point mutation involving substitution of
glutamic acid at position 6 to valine. Encoded in this hydrophobic mutation is both an …

Deoxy-sicklecell hemoglobin (HbS) polymerizes in 0.05 M phosphate buffer to form long
helical fibers. The reaction typically occurs when the concentration of HbS is about 165 …

This article describes a DNA‐like polymer that exhibits the ability to self‐assemble through
hydrogen bonding. We synthesized poly [1‐(4‐vinylbenzyl) thymine](PVBT) and 9 …

Three new Hb S variants containing β87 Leu, Trp, or Asp instead of Thr were expressed in
yeast in order to further define the role of the β87 position in stability and polymerization of …

Abstract Models for the structure of the fibers of deoxy sickle cell hemoglobin (Hb S, β6
Glu→ Val) have been obtained from X‐ray and electron microscopic studies. Recent …

We present simulation results on the self-assembly behavior of sickle hemoglobin (HbS). A
coarse-grained HbS model, which contains hydrophilic and hydrophobic particles explicitly …

Sickle hemoglobin (HbS) polymerization initiates in the deoxy state with the binding of
hydrophobic patch formed by the isopropyl group of βVal6 residue of a hemoglobin tetramer …

The polymerisation of deoxy sickle cell Haemoglobin (HbS) within the erythrocytes is the
primary molecular event responsible for the patho-physiology of the sickle cell disease …