Analogues of oxytocin containing D-Trp, 2-amino-1, 2, 3, 4-tetrahydronaphthalene-1-
carboxylic acid (Atc) or 1, 2, 3, 4-tetrahydro-β-carboline-1-carboxylic acid (Car) with R or S …

The peptide oxytocin (OT) antagonist atosiban, approved for tocolytic use in Europe (under
the tradename Tractocile), represents an important new therapeutic advance for the …

New insights into the structure− activity relationship of the peptide hormone oxytocin are
presented. Incorporation of the novel cis-prolyl mimic 2, 2-dimethyl-1, 3-thiazolidine-4 …

A number of structurally novel cyclic hexapeptides have been characterized as potent and
selective oxytocin (OT) antagonists in vitro. As a representative of this class of compounds, L …

Analogs of oxytocin containing tetrahydroisoquinoline carboxylic acid (Tic) of L or D
configuration in position 2 were synthesized and their biological activities were tested. Both …

We report the solid-phase synthesis and some pharmacological properties of twenty
oxytocin (OT) analogues. Basic modifications at position 7 (introduction of α-aminoisobutyric …

Eleven new analogues were synthesized by modification of the potent oxytocin antagonist
(OTA)(S) Pmp1, d‐Trp2, Pen6, Arg8‐Oxytocin, or PA (parent antagonist), in which (S) Pmp …

As part of a program in which we are attempting tosynthesize in vivo antagonists of oxytocin,
the following four analogues were synthesized and tested for antagonistic activitiesin rat …

A library of compounds targeted to the vasopressin/oxytocin family of receptors was
screened for activity at a cloned human oxytocin receptor using a reporter gene assay …

Very few nonpeptide oxytocin agonists have currently been reported, and none of them
seem suitable for the in vivo investigation of the oxytocin mediated functions. In an attempt to …