Uric acid and the state of the intrarenal renin-angiotensin system in humans. Background
Experimental hyperuricemia is marked by an activated intrarenal renin-angiotensin system …

Although hyperuricemia has long been associated with renal disease, uric acid has not
been considered as a true mediator of progression of renal disease. The observation that …

Serum uric acid was first noted to be associated with increased BP by Frederick Mohamed in
the 1870s. Although the link was rediscovered periodically over the years, it generally was …

A link between serum uric acid and the development of hypertension was first hypothesized
in the 1870s. Although numerous epidemiologic studies in the 1980s and 1990s suggested …

Background Uric acid (UA) levels correlate positively with the prevalence of chronic kidney
disease (CKD) and/or hypertension. We tested the hypothesis that UA may also have a link …

Recent epidemiologic and experimental evidence suggests that serum uric acid (UA) is an
independent risk factor for cardiovascular and renal diseases. However, endothelial …

In humans, uric acid is the main urinary metabolite of purines. Serum levels are higher
compared with other mammalians. Uric acid is an antioxidant and perhaps helps to control …

Background Plasma uric acid has been associated with hypertension in a variety of
disorders, and has been shown to be predictive of hypertension. The mechanistic role of uric …

Uric acid may mediate aspects of the relationship between hypertension and kidney disease
via renal vasoconstriction and systemic hypertension. To investigate the relationship …

BACKGROUND: Despite recent evidence, the role of uric acid as a causal factor in the
pathogenesis and progression of kidney disease remains controversial, partly because of …