Spinal cord ischemic injury: Development of a new model in the rat

GK Kanellopoulos, H Kato, CY Hsu, NT Kouchoukos - Stroke, 1997 - Am Heart Assoc
Background and Purpose Spinal cord ischemic injury (SCII) with resulting paralysis is a
major cause of morbidity after operations on the thoracic aorta. Since the vascular supply to …

Spinal cord ischemia: development of a model in the mouse

L Lang-Lazdunski, K Matsushita, L Hirt, C Waeber… - Stroke, 2000 - Am Heart Assoc
Background and Purpose—Spinal cord ischemia with resulting paraplegia is a devastating
complication of thoracoabdominal aortic surgery. Experimental models of spinal cord …

Development of a simplified spinal cord ischemia model in mice

Z Wang, W Yang, GW Britz, FW Lombard… - Journal of neuroscience …, 2010 - Elsevier
Use of genetically manipulated mice facilitates understanding pathological mechanisms in
many diseases and contributes to therapy development. However, there is no practical and …

Ischemic dose-response in the spinal cord: both immediate and delayed paraplegia

PD Smith, F Puskas, X Meng, D Cho… - Journal of Surgical …, 2012 - Elsevier
BACKGROUND: Paraplegia remains a significant complication of thoracoabdominal aortic
surgery. The study of this spinal cord ischemia and reperfusion injury (SCIR) has been …

Spinal cord injury in experimental thoracic aortic occlusion: investigation of combined methods of protection

JR Elmore, P Gloviczki, CM Harper Jr, MJ Murray… - Journal of vascular …, 1992 - Elsevier
The efficacy of combined methods of spinal cord protection during thoracoabdominal aortic
reconstruction was evaluated because a recent clinical study failed to substantiate the value …

Ischemia and reperfusion injury of the spinal cord: experimental strategies to examine postischemic paraplegia

F Simon, A Oberhuber - Neural Regeneration Research, 2016 - journals.lww.com
Thoracoabdominal aortic replacement, necessary in case of injuries, aneurysms and
dissections, shows a high complication rate as a consequence of the perioperative …

Degeneration of axons in the corticospinal tract secondary to spinal cord ischemia in rats

KS Blisard, F Follis, R Wong, KB Miller, JA Wernly… - Spinal Cord, 1995 - nature.com
Occlusion of the thoracic aorta and both subclavian arteries (XC) in the rat model produces
spastic paraplegia. In order to characterize the lesion of white matter, 14 male Sprague …

Effect of proximal arterial perfusion pressure on function, spinal cord blood flow, and histopathologic changes after increasing intervals of aortic occlusion in the rat

Y Taira, M Marsala - Stroke, 1996 - Am Heart Assoc
Background and Purpose Cross-clamping of the thoracic aorta results in spinal cord
ischemia and prominent systemic hypertension. Using a rat model of transient spinal cord …

Transient spinal ischemia in the rat: characterization of behavioral and histopathological consequences as a function of the duration of aortic occlusion

M Marsala, TL Yaksh - Journal of Cerebral Blood Flow & …, 1994 - journals.sagepub.com
To characterize the behavioral and histopathological changes that occur in spinal cord after
transient ischemia, reversible occlusion of the descending aorta was achieved in the …

Experimental spinal cord ischemia: model characterization and improved outcome with arterial hypertension

TJK Toung, Y Chang, M Williams, BJ Crain… - Critical care …, 2004 - journals.lww.com
Objective: Paraplegia from spinal cord ischemia is a devastating complication of
thoracoabdominal aortic aneurysm repair. Perioperative hypoperfusion of the spinal cord is …