Virus-like particles of SARS-CoV-2 as virus surrogates: Morphology, immunogenicity, and Internalization in neuronal cells

CS Kumar, B Singh, ZA Rizvi, HA Parray… - ACS Infectious …, 2022 - ACS Publications
The engineering of virus-like particles (VLPs) is a viable strategy for the development of
vaccines and for the identification of therapeutic targets without using live viruses. Here, we …

[HTML][HTML] An Overview of Recent Developments in the Application of Antigen Displaying Vaccine Platforms: Hints for Future SARS-CoV-2 VLP Vaccines

DI Setyo Utomo, H Suhaimi, NA Muhammad Azami… - Vaccines, 2023 - mdpi.com
Recently, a great effort has been devoted to studying attenuated and subunit vaccine
development against SARS-CoV-2 since its outbreak in December 2019. It is known that …

[HTML][HTML] Nanograms of SARS-CoV-2 spike protein delivered by exosomes induce potent neutralization of both delta and omicron variants

M Cacciottolo, Y Li, JB Nice, MJ LeClaire, R Twaddle… - PLoS …, 2023 - journals.plos.org
Exosomes are emerging as potent and safe delivery carriers for use in vaccinology and
therapeutics. A better vaccine for severe acute respiratory syndrome coronavirus 2 (SARS …

[HTML][HTML] Single-shot AAV-vectored vaccine against SARS-CoV-2 with fast and long-lasting immunity

F Wu, S Luo, Y Zhang, Y Ou, H Wang, Z Guo… - … Pharmaceutica Sinica B, 2023 - Elsevier
Due to the insufficient long-term protection and significant efficacy reduction to new variants
of current COVID-19 vaccines, the epidemic prevention and control are still challenging …

[HTML][HTML] Mechanistic and therapeutic implications of extracellular vesicles as a potential link between Covid-19 and cardiovascular disease manifestations

G Pironti, DC Andersson, LH Lund - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs), which are cell released double layered membrane particles,
have been found in every circulating body fluid, and provide a tool for conveying diverse …

Nano-multilamellar lipid vesicles promote the induction of SARS-CoV-2 immune responses by a protein-based vaccine formulation

MJ Rodrigues-Jesus, MT de Pinho Favaro… - … , Biology and Medicine, 2022 - Elsevier
The development of safe and effective vaccine formulations against severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) represents a hallmark in the history of vaccines …

[HTML][HTML] Development of fluorescence-tagged SARS-CoV-2 virus-like particles by a tri-cistronic vector expression system for investigating the cellular entry of SARS …

YS Chang, LW Chu, ZY Chen, JS Wu, WC Su, CJ Yang… - Viruses, 2022 - mdpi.com
Severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) has caused the
pandemic that began late December 2019. The co-expression of SARS-CoV-2 structural …

[HTML][HTML] Development of novel SARS-CoV-2 viral vectors

H Liu, D Liu - Scientific Reports, 2023 - nature.com
The authentic SARS-CoV-2 requires to be handled in Biosafety Level 3 laboratories, which
restrains investigation by the broader scientific community. Here, we report the development …

[HTML][HTML] Preclinical immunogenicity and efficacy of a candidate COVID-19 vaccine based on a vesicular stomatitis virus-SARS-CoV-2 chimera

AS Espeseth, M Yuan, M Citron, L Reiserova… - …, 2022 - thelancet.com
Background To investigate a vaccine technology with potential to protect against
coronavirus disease 2019 (COVID-19) and reduce transmission of severe acute respiratory …

[HTML][HTML] A mouse model for SARS-CoV-2 infection by exogenous delivery of hACE2 using alphavirus replicon particles

YN Zhang, XD Li, ZR Zhang, HQ Zhang, N Li, J Liu… - Cell Research, 2020 - nature.com
Dear Editor, Since the outbreak of a novel coronavirus disease (COVID-19) in late 2019, it
has spread rapidly and developed into a global pandemic. As of August 12, 2020, more than …