Glucose intolerance in adults born with intrauterine growth retardation (IUGR) may involve
peripheral insulin resistance and/or abnormal endocrine pancreas development during fetal …

We determined in vivo and in vitro pancreatic islet insulin secretion and glucose metabolism
in fetuses with intrauterine growth restriction (IUGR) caused by chronic placental …

Aims/hypothesis: We have shown that perinatal malnutrition decreases beta-cell mass at
birth and impairs the adaptation of the endocrine pancreas to a subsequent pregnancy. The …

Fetal hyperinsulinemia is assumed to play a key role in the pathogenesis of diabetic
fetopathy. To investigate the role of enhanced fetal B-cell mass as one cause of fetal …

Human fetuses with severe intrauterine growth restriction (IUGR) have less pancreatic
endocrine tissue and exhibit β-cell dysfunction, which may limit β-cell function in later life …

As increasing numbers of babies born preterm survive into adulthood, it is becoming clear
that, in addition to the well-described risks of neurodevelopmental sequelae, there also are …

The fetal endocrine pancreas plays an important part during intrauterine life. The fetal B cell
produces insulin, which is known to be a most important growth-promoting factor. In …

Low birth weight is an important risk factor for type 2 diabetes in later life. Maturity-onset
diabetes of the young has been linked to genetic sequence abnormalities in transcription …

The role of nutrition on the development of the endocrine pancreas was studied in a rat
model obtained by maternal food restriction. A 50% food restriction was applied to female …

Abstract Background and Objectives: The aim of this study was to investigate the possibility
that intrauterine growth retardation (IUGR) causes alterations of glucose tolerance, insulin …