Dual specificity phosphatase 1 (DUSP1) dephosphorylates and, hence, regulates the activity
of MAP kinases. The present study investigated the effect of DUSP1 on inflammatory gene …

Glucocorticoids (GCs), which are used in the treatment of immune-mediated inflammatory
diseases, inhibit the expression of many inflammatory mediators. They can also induce the …

Activation of the mitogen-activated protein kinase (MAPK) cascade after Toll-like receptor
stimulation enables innate immune cells to rapidly activate cytokine gene expression. A …

Although dual-specificity phosphatase 5 (DUSP5), which inactivates extracellular signal-
regulated kinase (ERK), suppresses tumors in several types of cancer, its functional roles …

Glucocorticoids act on the glucocorticoid receptor (NR3C1) to repress inflammatory gene
expression. This is central to their anti-inflammatory effectiveness and rational improvements …

Macrophages play a fundamental role in human chronic diseases such as rheumatoid
arthritis, atherosclerosis, and cancer. In the present study, we demonstrated that dual …

Innate immune responses are critically dependent on MAPK (mitogen-activated protein
kinase) signalling pathways, in particular JNK (c-Jun N-terminal kinase) and p38 MAPK …

The role of dual specificity phosphatase 1 (DUSP1) in inducible nitric oxide synthase (iNOS)
expression in A549 human pulmonary epithelial cells, J774 mouse macrophages and …

The mitogen-activated protein kinase (MAPK) cascades are activated in innate immune cells
such as macrophages upon the detection of microbial infection, critically regulating the …

Dual specificity phosphatase DUSP1 (otherwise known as mitogen-activated phosphatase 1
or MKP-1) dephosphorylates MAPKs, particularly p38, and negatively regulates innate …