Malignant cells usually show altered gap junctional intercellular communication and are
often associated with aberrant expression or localization of connexins. Transfection of …

Gap junctional intercellular communication (GJIC) is considered to play a key role in the
maintenance of tissue independence and homeostasis in multicellular organisms by …

In order to examine whether different connexin gene species exert different degrees of tumor-
suppressing activity, we characterized growth characteristics of a gap junction-deficient …

Many lines of evidence support the hypothesis that connexins form a family of tumor‐
suppressor genes. Transfection of connexin43 (Cx43) into rat C6 glioma cells have revealed …

Connexin genes exert negative growth control when transfected into various types of tumor
cell lines. We previously demonstrated that connexin 26 (Cx26) suppresses in vitro and in …

Gap junctions, or connexons, are formed by connexin proteins and connect most cells in the
body to form water-filled channels directly linking the cytoplasm. Among the molecules …

Cells within a tissue continuously interact to coordinate normal tissue functions and maintain
homeostasis. Gap junctional communication (GJC), mediated by the connexin protein family …

Gap junctions are cellular structures which permit direct exchanges of small molecules from
cytoplasm to cytoplasm in most of the cells of metazoan organisms. For four decades, it has …

Connexins (cx), structural components of gap junction, are believed to play a role in the
regulation of cell proliferation and suppression of the neoplastic phenotype. We used human …

Evidence is accumulating that connexin (Cx) genes form a family of tumor-suppressor
genes. Our long-standing study revealed that, in almost all tumors, some abnormality in gap …