Abstract The connexin 26 (CX26) gene suppresses the growth of HeLa cells in vitro and in
vivo. We explored the possibility that the Cx26 gene not only suppresses growth but can …

The mechanism by which gap junction proteins, connexins, act as potent tumor suppressors
remains poorly understood. In this study human breast tumor cells were found to exhibit …

Accumulating evidence indicates that gap junctions play an important role in the
maintenance of normal cell growth, so that genes for the connexin gap junction proteins form …

The membrane-spanning connexin proteins form microscopic intercellular channels that
directly connect the cytoplasms of adjacent cells and as such have been implicated in …

Connexins (Cx) are members of a protein family that forms intercellular channels localised in
gap junction (GJ) plaques and single transmembrane channels called hemichannels. They …

Connexins are proteins that form the connexons, gap junction structures, which allow cells to
communicate. Phosphorylation of connexins has been found to impair this communication …

During multistage carcinogenesis, multiple genetic changes progressively accumulate in a
cell until it acquires a complete set of altered genes necessary for malignant phenotype …

The purpose of this paper is to provide a brief overview of current thinking on the role of
connexins, in particular Cx43, in growth regulation, and a more detailed discussion as to …

Connexin (Cx) genes have negative growth effects on tumor cells with certain cell specificity.
We have previously reported that Cx32 is specifically downregulated in human renal cell …

Alteration of gap-junctional intercellular communication (GJIC) has long been proposed to
be involved in carcinogenesis. Previously, we reported that the level of gap junctional …