Herpes simplex thymidine kinase/ganciclovir (HSVtk/GCV) gene therapy has been used for
the treatment of a variety of cancers. Its efficacy is enhanced by the bystander effect that …

We examined changes in the expression and localization of connexin proteins and
transcripts by means of immunofluorescence and in situ hybridization in normal conditions …

The loss or alteration of gap junctional intercellular communication (GJIC) has long been
proposed to play an important role in the process of carcinogenesis. In this study we …

The inhibition of gap‐junctional intercellular communication (GJIC) between initiated and
surrounding normal cells by tumor promoters is believed to be important in the promotion …

Fifty years ago, tumour cells were found to lack electrical coupling, leading to the hypothesis
that loss of direct intercellular communication is commonly associated with cancer onset and …

The development of the most efficacious strategy for the prevention and treatment of cancers
is based on understanding the underlying mechanisms of carcinogenesis. This includes the …

The connexin 26 (Cx26) gene encodes a protein involved in gap junctional intercellular
communication and is a putative tumor suppressor. We constructed a Cx26 adenovirus …

Gap junction intercellular communication (GJIC) is considered to play roles in regulation of
homeostasis, development and differentiation of many tissues. In the present study, using …

C6 glioma cells express low levels of the gap junction protein connexin 43 and its mRNA
and display very weak dye coupling. When implanted into the rat cerebrum, these cells …

Connexins are gap junction proteins that assemble into channels that mediate direct
intercellular communication. Connexins are well-documented tumor suppressors and are …