Tissue fibrosis and chronic inflammation are common causes of progressive organ damage,
including progressive renal disease, leading to loss of physiological functions. Recently, it …

Damage-associated molecular patterns (DAMP) trigger innate immune response and
exacerbate inflammation to combat infection and cellular damage. Identifying DAMPs and …

NLRP-3 inflammasome is one of several intracellular danger recognition platforms that
integrates infectious or non-infectious types of danger into the expression of pro …

Chronic injury often triggers maladaptive wound healing responses leading to the
development of tissue fibrosis and subsequent organ malfunction. Inflammation is a key …

Endogenous ligands released from damaged cells, so-called damage-associated molecular
pattern molecules (DAMPs), activate innate signaling pathways including the TLRs. We …

This article is the second part of a review that addresses the role of damage-associated
molecular patterns (DAMPs) in human diseases by presenting examples of traumatic …

Renal ischemia reperfusion injury (IRI), a common event after renal transplantation, causes
acute kidney injury (AKI), increases the risk of delayed graft function (DGF), primes the donor …

Inflammation is a complex biologic response that is essential for eliminating microbial
pathogens and repairing tissue after injury. AKI associates with intrarenal and systemic …

Renal fibrosis is a common consequence of various progressive nephropathies, including
obstructive nephropathy, and ultimately leads to kidney failure. Infiltration of inflammatory …

There is a close spatial and temporal relationship between macrophage accumulation and
active renal fibrosis in human and experimental kidney disease. Different subtypes of …