Monocyte-derived macrophages can determine the outcome of the immune response and
whether this response contributes to tissue repair or mediates tissue destruction. In addition …

Acute kidney injury (AKI) is a renal disease with a high incidence and mortality. Currently,
there are no targeted therapeutics for preventing and treating AKI. Macrophages, important …

The acutely injured mammalian kidney mounts a cellular and molecular response to repair
itself. However, in patchy regions such intrinsic processes are impaired and dysregulated …

Kidney ischemia reperfusion injury is a major cause of morbidity in both allograft and native
kidneys. Ischemia reperfusion-induced acute kidney injury is characterized by early …

Toll-like receptors (TLR) classically recognize pathogen-associated danger signals but are
also activated via endogenous ligands. For evaluation of their role in inflammatory kidney …

The innate immune system is the first line of defense against invading pathogens or sterile
injuries. Pattern recognition receptors (PRR) sense molecules released from inflamed or …

Kidney fibrosis following kidney injury is an unresolved health problem and causes
significant morbidity and mortality worldwide. In a study into its molecular mechanism, we …

Omega-3 fatty acid docosahexaenoic acid is converted to potent resolvins (Rv) and protectin
D1 (PD1), two newly identified families of natural mediators of resolution of inflammation. We …

High levels of aldosterone impair renal function by activating proinflammatory and profibrotic
pathways. However, the molecular mechanism underlying aldosterone‐induced …

Acute kidney injury (AKI) is defined by a rapid decline in renal function. Regardless of the
initial cause of injury, the influx of immune cells is a common theme during AKI. While an …