Cell transplantation‐induced hepatic ischemia and recruitment of vasoconstrictors (eg,
endothelin‐1; Edn1) leads to clearance of transplanted cells and poses problems for liver …

To optimize strategies for liver‐directed cell therapy, prevention of initial transplanted cell
losses is particularly important for subsequent liver repopulation. After cell transplantation in …

Engraftment of transplanted cells is critical for liver‐directed cell therapy, but most
transplanted cells are rapidly cleared from liver sinusoids by proinflammatory …

Endothelin-1 can induce microcirculatory disorders by mediating sinusoidal
vasoconstriction, lowering the perfusion rate and promoting leukocyte adhesion, all of which …

Background & Aims For liver-directed cell therapy, efficient engraftment of transplanted cells
is critical. This study delineated whether anti-inflammatory and endothelial disrupting …

This study investigated the effects of dual endothelin (ET) receptor blockade in rat models of
liver ischemia and reperfusion injury (IRI). Three models of IRI were used:(1) in vivo total …

Background. Perturbations in specific liver cell compartments benefit transplanted cell
engraftment and/or proliferation. We analyzed whether cytotoxic drugs interfering with the …

Reperfusion injury remains one of the major problems in transplantation. Free radicals and
disturbance of microcirculation are the supposed main contributors. Recent evidence shows …

Reconstitution of healthy endothelial cells in vascular beds offers opportunities for
mechanisms in tissue homeostasis, organ regeneration, and correction of deficient …

Background Angiogenesis plays a pivotal role in splanchnic hyperaemia and portosystemic
collateral formation in cirrhosis. Endothelin‐1 (ET‐1), an endothelium‐derived …