Several recent reports have shown that plasma concentrations of digoxin increase when
quinidine is administered along with digoxin; the present study was designed to explore the …

1 This study was designed to evaluate pharmacokinetically the digoxin‐quinidine interaction
in patients with atrial fibrillation. 2 Five patients on maintenance digoxin therapy were given …

Administration of quinidine with digoxin increased serum digoxin concentrations in 79
patients and five volunteers. In 38 patients on a constant glycoside maintenance dose, the …

The interactions between digoxin and quinine and quinidine that affect the renal and biliary
clearances of digoxin were investigated in eight healthy subjects. Digoxin (0.5 to 0.75 …

The time course of the rise in serum digoxin concentration was followed in 18 patients
treated with digoxin as quinidine treatment was started with a loading dose. The mean …

Digoxin-quinidine interaction is well documented In the literature. The mechanism is,
however, unknown. Previously, it was shown that quinidine reduced digoxin secretion by …

To explore a possible interaction between digoxin and verapamil, a single‐dose kinetic
study of digoxin was performed and then repeated after 10 days of verapamil treatment in …

The serum digoxin concentration increased in 25 of 27 study patients (93%), and the mean
serum digoxin concentration rose from 1.4 ng/ml to 3.2 ng/ml during quinidine therapy …

To evaluate the possible effect of quinidine on digoxin bioavailability, the steady state
digoxin kinetics was examined with and without concomitant quinidine therapy, in 7 cardiac …

Methods for testing digoxin bioavailability were compared in single-dose crossover studies
using eight healthy male subjects. Digoxin (0.75 mg) was given by intravenous infusion …