We generated transgenic mice that carry 4.6 kb of the mouse galanin gene fused to 2.5 kb of
the rat PRL promoter. In all transgenic lines that carried and transmitted the transgene, there …

Galanin is a biologically active 29 amino acid peptide, widely distributed in the central and
peripheral nervous system, and most abundantly in the hypothalamus where it may serve in …

The neuropeptide galanin is predominantly expressed by the lactotrophs (the prolactin
secreting cell type) in the rodent anterior pituitary and in the median eminence and …

Galanin is a widely distributed regulatory peptide which modulates the pituitary secretion of
PRL and GH. Estrogen administration strongly stimulates galanin gene expression in the rat …

Estrogen is a robust stimulator of galanin synthesis and secretion in the anterior pituitary.
Galanin is colocalized in lactotrophs in the estrogen-treated anterior pituitary, and its roles in …

The peptide galanin is synthesized within and secreted from specific cells of the anterior
pituitary gland. Previous studies showed that GH-releasing hormone (GHRH) stimulates …

Galanin is a peptide widely distributed throughout vertebrate central and peripheral nervous
systems. Although its precise physiologic role is unknown, it can stimulate the pituitary …

Studies evaluating estrogen-induced anterior pituitary tumors revealed a strong direct
correlation between expression of the peptide galanin and tumor growth. To evaluate further …

Studies on the regulation of galanin expression in the epithelial cells of the anterior pituitary
gland have provided a wealth of insight into the cellular and molecular biology of this unique …

Recent evidence suggests that galanin, may regulate prolactin (PRL) secretion during
lactation. In this article, we describe the regulation of anterior pituitary galanin and PRL gene …