Objective PTC-specific analysis identified novel fusions involving RET, BRAF, NTRK1,
NTRK3, AGK and ALK genes in adults and pediatric PTCs. Although many novel fusions are …

Simple Summary NTRK fusion genes are important but not well studied molecular markers
in thyroid cancer. Their identification could help improve diagnosis and prognosis, and …

Background: Pediatric papillary thyroid carcinoma (PTC) is a rare malignancy, but with
increasing incidence. Pediatric PTCs have distinct clinical and pathological features and …

Most studies for comprehensive molecular profiling of papillary thyroid carcinoma (PTC)
have been performed before the 2017 World Health Organization (WHO) classification, in …

Objective Fusions involving neurotrophic tyrosine receptor kinase (NTRK) are known
oncogenic drivers in a broad range of tumor types. It recently gained attention as a predictor …

Context Fusion oncogenes, especially those involving RET or NTRK, are known drivers of
papillary thyroid cancer (PTC). They are prevalent in pediatric patients and correlate with …

Pediatric papillary thyroid carcinoma (PPTC) is clinically distinct from adult-onset disease.
Although there are higher rates of metastasis and recurrence in PPTC, prognosis remains …

BACKGROUND An increase in thyroid cancers, predominantly papillary thyroid carcinoma
(PTC), has been recently reported in children. METHODS The histopathology of 28 …

Introduction Fusion oncogenes (eg, NTRK, RET, ALK, BRAF) are rare genetic events in
papillary thyroid carcinoma (PTC). It is still unclear regarding the similarities and differences …

BACKGROUND Molecular characterization in pediatric papillary thyroid cancer (PTC),
distinct from adult PTC, is important for developing molecularly targeted therapies for …