Background Airway inflammation is associated with asthma exacerbation risk, treatment
response, and disease mechanisms. Objective This study aimed to identify and validate a …

BACKGROUND: Previous studies have identified clinical or inflammatory phenotypes of
asthma on the basis of clinical and demographic parameters or sputum cell counts; …

Biomarkers that predict responses to oral corticosteroids (OCS) facilitate patient selection for
asthma treatment. We hypothesised that asthma patients would respond differently to OCS …

Background Sputum analysis in asthmatic patients is used to define airway inflammatory
processes and might guide therapy. Objective We sought to determine differential gene and …

Asthma is characterised by heterogeneous clinical phenotypes. Our objective was to
determine molecular phenotypes of asthma by analysing sputum cell transcriptomics from …

Background Asthma is a chronic airway inflammatory disease; however, the molecular
mechanisms that underlie asthma exacerbation are only partially understood. Objective To …

Background Improved diagnostic tools for predicting future exacerbation frequency in
asthmatic patients are required. A sputum gene expression signature of 6 biomarkers (6 …

Background Asthma exacerbations are associated with heightened asthma symptoms,
which can result in hospitalization in severe cases. However, the molecular immunologic …

Background: Type 2 (T2) inflammation drives airway dysfunction in many patients with
asthma; yet, we lack a comprehensive understanding of the airway immune cell types and …

Background and objective Asthma is a heterogeneous disease with various clinical,
inflammatory and molecular phenotypes. We studied sputum cytokine mRNA expression …