In type 2 diabetes, it has been proposed that pancreatic beta-cell dysfunction is promoted by
oxidative stress caused by NADPH oxidase (NOX) overactivity. Five different NOX enzymes …

It has been proposed that pancreatic beta-cell dysfunction in type 2 diabetes is promoted by
oxidative stress caused by NADPH oxidase (Nox) over-activity. The aim of the present study …

Defects in insulin secretion by pancreatic cells and/or decreased sensitivity of target tissues
to insulin action are the key features of type 2 diabetes. It has been shown that excessive …

Increased intracellular generation of reactive oxygen species [ROS] has been implicated in
the pathology of metabolic [diabetes] and neurodegenerative [Alzheimer's] diseases …

Aims/hypothesis Upregulation of the reactive oxygen species (ROS)-producing enzyme
NADPH oxidase (NOX)-1 in islets and beta cells follows acute exposure to inflammatory …

OBJECTIVE The role of NOX2-containing NADPH oxidase in the development of diabetes is
not fully understood. We hypothesized that NOX2 deficiency decreases reactive oxygen …

In type 2 diabetes, metabolic stress has a negative impact on pancreatic β-cell function and
survival (T2D). Although the pathogenesis of metabolic stress is complex, an imbalance in …

High glucose-induced oxidative stress and increased NADPH oxidase-2 (NOX2) activity
may contribute to the progressive decline of the functional β-cell mass in type 2 diabetes. To …

NADPH oxidases (NOXs) are comprised of different isoforms, NOX1 to 5 and Duox1 and 2,
and they trigger diabetic nephropathy (DN) in the patients with diabetes mellitus. Recently, it …

Objective—Obesity is associated with insulin resistance and adipose tissue inflammation.
Reactive oxygen species (ROS) increase in adipose tissue during the development of …